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ROCK1 gene

Known as: Rho-Associated, Coiled-Coil Containing Protein Kinase 1 Gene, ROCK1, p160-ROCK 
This gene is involved in the regulation of cell division, cytoskeletal remodeling and smooth muscle contraction.
National Institutes of Health

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Related topics

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Cell AdhesionCytoskeletal ModelingPhosphorylationROCK1 protein, human

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ROCK1 wt Allele

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2019
2019
MiR-144 Inhibits Tumor Growth and Metastasis in Osteosarcoma via Dual-suppressing RhoA/ROCK1 Signaling Pathway
Several microRNAs (miRNAs) have been found expressed differentially in osteosarcoma (OS), so they may function in the onset and… 
2018
2018
miR-202-5p inhibits the migration and invasion of osteosarcoma cells by targeting ROCK1
Many studies have shown that microRNA regulates the development and treatment of osteosarcoma (OS). In many human cancer studies… 
2017
2017
MicroRNA-101 inhibits proliferation, migration and invasion in osteosarcoma cells by targeting ROCK1.
Osteosarcoma is a rare malignant bone tumor in adolescents, with high degree of malignancy, and highly incidence of recurrence… 
2015
2015
MiR-506 suppresses cell proliferation and tumor growth by targeting Rho-associated protein kinase 1 in hepatocellular carcinoma.
2015
2015
Discovery of Novel ROCK1 Inhibitors via Integrated Virtual Screening Strategy and Bioassays
Rho-associated kinases (ROCKs) have been regarded as promising drug targets for the treatment of cardiovascular diseases, nervous… 
2015
2015
Abrogation of airway hyperresponsiveness but not inflammation by rho kinase insufficiency
Major features of allergic asthma include airway hyperresponsiveness (AHR), eosinophilic inflammation, and goblet cell metaplasia… 
2015
2015
The effect of ROCK on TNF-α-induced CXCL8 secretion by intestinal epithelial cell lines is mediated through MKK4 and JNK signaling.
Highly Cited
2014
Highly Cited
2014
MiR-186 targets ROCK1 to suppress the growth and metastasis of NSCLC cells
MicroRNAs (miRNAs) act as oncogenes or tumor suppressors in human cancers. Increasing evidence shows that deregulation of miRNAs… 
Highly Cited
2011
Highly Cited
2011
In vivo activation of ROCK1 by insulin is impaired in skeletal muscle of humans with type 2 diabetes.
To determine whether serine/threonine ROCK1 is activated by insulin in vivo in humans and whether impaired activation of ROCK1… 
2011
2011
ROCK1 functions as a critical regulator of stress erythropoiesis and survival by regulating p53.
Erythropoiesis is a dynamic, multistep process whereby hematopoietic stem cells differentiate toward a progressively committed… 
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