ROCK1 protein, human

Known as: Rho-Associated, Coiled-Coil Containing Protein Kinase 1, ROCK1, Rho-associated, coiled-coil containing protein kinase 1, human 
Encoded by human ROCK1 Gene, Rho-Associated Coiled-Coil Containing Protein Kinase 1 is a Ser/Thr kinase activated when bound to GTP-bound Rho. The… (More)
National Institutes of Health

Papers overview

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Highly Cited
2012
Highly Cited
2012
Several lines of evidence suggest that mitochondrial dysfunction plays a critical role in the pathogenesis of microvascular… (More)
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Highly Cited
2011
Highly Cited
2011
PURPOSE MicroRNAs (miRNA) have been documented playing a critical role in cancer development and progression. In this study, we… (More)
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Highly Cited
2008
Highly Cited
2008
In three-dimensional matrices cancer cells move with a rounded, amoeboid morphology that is controlled by ROCK-dependent… (More)
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Highly Cited
2008
Highly Cited
2008
Although Rho-associated kinase (ROCK) activity has been implicated in cardiovascular diseases, the tissue- and isoform-specific… (More)
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Highly Cited
2008
Highly Cited
2008
Y-27632, an inhibitor of the Rho-associated kinase ROCK, is a therapeutic lead for Huntington disease (HD). The downstream… (More)
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Highly Cited
2006
Highly Cited
2006
Ventricular myocyte hypertrophy is an important compensatory growth response to pressure overload. However, pathophysiological… (More)
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Highly Cited
2006
Highly Cited
2006
Nicotinamide adenine dinucleotide (NAD)+-dependent sirtuins have been identified to be key regulators in the lifespan extending… (More)
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Highly Cited
2005
Highly Cited
2005
BACKGROUND Rho GTPase and its downstream target, Rho-associated kinase (ROCK), have been implicated in diverse cardiovascular… (More)
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Highly Cited
2000
Highly Cited
2000
We tested the contribution of the small GTPase Rho and its downstream target p160ROCK during the early stages of axon formation… (More)
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Highly Cited
1997
Highly Cited
1997
p160ROCK is a serine/threonine protein kinase that binds selectively to GTP-Rho and is activated by this binding. To identify its… (More)
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