RNF43 gene

Known as: RNF124, RNF43, DKFZp781H0392 
This gene is involved in both protein ubiquitination and the Wnt signaling pathway.
National Institutes of Health

Papers overview

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2017
2017
Forward genetic screens with CRISPR–Cas9 genome editing enable high-resolution detection of genetic vulnerabilities in cancer… (More)
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Highly Cited
2015
Highly Cited
2015
In Rspondin-based 3D cultures, Lgr5 stem cells from multiple organs form ever-expanding epithelial organoids that retain their… (More)
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Highly Cited
2014
Highly Cited
2014
We report somatic mutations of RNF43 in over 18% of colorectal adenocarcinomas and endometrial carcinomas. RNF43 encodes an E3… (More)
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Review
2014
Review
2014
Lgr5 was originally discovered as a common Wnt target gene in adult intestinal crypts and colon cancer. It was subsequently… (More)
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Highly Cited
2014
Highly Cited
2014
Gastric cancer is a heterogeneous disease with diverse molecular and histological subtypes. We performed whole-genome sequencing… (More)
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Highly Cited
2013
Highly Cited
2013
A growing number of agents targeting ligand-induced Wnt/β-catenin signaling are being developed for cancer therapy. However… (More)
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2013
2013
Mucinous carcinomas represent a distinct morphological subtype which can arise from several organ sites, including the ovary, and… (More)
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Highly Cited
2012
Highly Cited
2012
LGR5+ stem cells reside at crypt bottoms, intermingled with Paneth cells that provide Wnt, Notch and epidermal growth factor… (More)
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Highly Cited
2012
Highly Cited
2012
Opisthorchis viverrini–related cholangiocarcinoma (CCA), a fatal bile duct cancer, is a major public health concern in areas… (More)
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Highly Cited
2011
Highly Cited
2011
More than 2% of adults harbor a pancreatic cyst, a subset of which progresses to invasive lesions with lethal consequences. To… (More)
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