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RNF168 gene

Known as: FLJ35794, RING FINGER PROTEIN 168, RNF168 
National Institutes of Health

Related topics

Related topics

1 relation
RNF2 gene

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2017
2017
Novel Combined Immune Deficiency and Radiation Sensitivity Blended Phenotype in an Adult with Biallelic Variations in ZAP70 and RNF168
With the advent of high-throughput genomic sequencing techniques, novel genetic etiologies are being uncovered for previously… 
2014
2014
An RNF168 fragment defective for focal accumulation at DNA damage is proficient for inhibition of homologous recombination in BRCA1 deficient cells
The E3 ubiquitin ligase RNF168 is a DNA damage response (DDR) factor that promotes monoubiquitination of H2A/H2AX at K13/15… 
2014
2014
BCL10 regulates RNF8/RNF168-mediated ubiquitination in the DNA damage response
Timely and proper cellular response to DNA damage is essential for maintenance of genome stability and integrity. B-cell lymphoma… 
2014
2014
Dub3 controls DNA damage signalling by direct deubiquitination of H2AX
Highly Cited
2013
Highly Cited
2013
The ubiquitin specific protease USP34 promotes ubiquitin signaling at DNA double-strand breaks
Ubiquitylation plays key roles in DNA damage signal transduction. The current model envisions that lysine63-linked ubiquitin… 
2013
2013
Structural basis for role of ring finger protein RNF168 RING domain
Ubiquitin adducts surrounding DNA double-strand breaks (DSBs) have emerged as molecular platforms important for the assembly of… 
Highly Cited
2012
Highly Cited
2012
Ring Finger Nuclear Factor RNF168 Is Important for Defects in Homologous Recombination Caused by Loss of the Breast Cancer Susceptibility Factor BRCA1*
Background: RNF168 promotes chromosomal break localization of 53BP1 and BRCA1; 53BP1 loss rescues homologous recombination (HR… 
2012
2012
RNF8 and RNF168 but not HERC2 are required for DNA damage-induced ubiquitylation in chicken DT40 cells.
Highly Cited
2011
Highly Cited
2011
Genomic Instability, Defective Spermatogenesis, Immunodeficiency, and Cancer in a Mouse Model of the RIDDLE Syndrome
Eukaryotic cells have evolved to use complex pathways for DNA damage signaling and repair to maintain genomic integrity. RNF168… 
2010
2010
HERC2 coordinates ubiquitin-dependent assembly of DNA repair factors on damaged chromosomes
Regulatory ubiquitylation is emerging as an important mechanism to protect genome integrity in cells exposed to DNA damage1–9… 
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