HERC2 coordinates ubiquitin-dependent assembly of DNA repair factors on damaged chromosomes

@article{BekkerJensen2010HERC2CU,
  title={HERC2 coordinates ubiquitin-dependent assembly of DNA repair factors on damaged chromosomes},
  author={Simon Holst Bekker-Jensen and Jannie M. Rendtlew Danielsen and Kasper Fugger and Irina Gromova and Annika Nerstedt and Jiri Bartek and Jiri Lukas and Niels Mailand},
  journal={Nature Cell Biology},
  year={2010},
  volume={12},
  pages={412-412}
}
Regulatory ubiquitylation is emerging as an important mechanism to protect genome integrity in cells exposed to DNA damage1–9. However, the spectrum of known ubiquitin regulators of the DNA damage response (DDR) is limited and their functional interplay is poorly understood. Here, we identify HERC2 as a factor that regulates ubiquitin-dependent retention of repair proteins on damaged chromosomes. In response to ionising radiation (IR), HERC2 forms a complex with RNF8, a ubiquitin ligase… CONTINUE READING
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