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RIPK3 gene

Known as: RIPK3, RIP3, RECEPTOR-INTERACTING PROTEIN 3 
This gene plays a role in signal transduction and the activation of apoptosis.
National Institutes of Health

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ApoptosisPhosphorylationRIPK3 protein, humanSerine/Threonine Phosphorylation

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RIPK3 wt Allele

Papers overview

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2018
2018
Chemical Library Screens to Identify Pharmacological Modulators of Necroptosis.
Necroptosis is mediated by the formation of the detergent-insoluble necrosome complex between Ser/Thr kinases RIPK1 and RIPK3… 
2017
2017
RIPK1/RIPK3/MLKL-mediated necroptosis contributes to compression-induced rat nucleus pulposus cells death
The aim of this study was to systematically investigate the role of necroptosis in compression-induced rat nucleus pulposus (NP… 
2017
2017
Involvement of RIPK3-regulated necroptosis in IPF pathogenesis
Rationale: Alveolar epithelial cell (AEC) injury leading to cell death is involved in the process of fibrosis development during… 
2017
2017
RIPped for neuroinflammation
Correction to: Cell Research advance online publication 19 May 2017; doi:10.1038/cr.2017.75 During web production, there is an… 
2016
2016
RIPK3-dependent cell death and inflammasome activation in FLT3-ITD expressing LICs
Acute myeloid leukemia (AML) is sustained by leukemia-initiating cells (LICs) with blocked myeloid differentiation and increased… 
2016
2016
RIPK3 Is Largely Dispensable for RIG-I-Like Receptor- and Type I Interferon-Driven Transcriptional Responses to Influenza A Virus in Murine Fibroblasts
The kinase RIPK3 is a key regulator of cell death responses to a growing number of viral and microbial agents. We have found that… 
2015
2015
Ensembling and filtering: an effective and rapid in silico multitarget drug-design strategy to identify RIPK1 and RIPK3 inhibitors
AbstractNecroptosis, a programmed necrosis pathway, is witnessed in diverse human diseases and is primarily regulated by receptor… 
2013
2013
Autophagic cell death RIPs into tumors
The idea of ‘autophagic cell death’ has been the subject of some controversy, much of it focused on links between autophagy and… 
2012
2012
Nuclear Export Signal and Immunodominant CD8+ T Cell Epitope in Influenza A Virus Matrix Protein 1
Shuai Cao et al. recently identified and characterized a nuclear export signal (NES) in influenza A virus matrix protein 1 (M1… 
2007
2007
Cloning, overexpression, purification, and characterization of receptor-interacting protein 3 truncation inEscherichia coli
To facilitate structural studies of receptor-interacting protein 3 (RIP3), we developed a large-scale expression system of a… 
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