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RG 13022

Known as: 3-Pyridineacetonitrile, alpha-((3,4-dimethoxyphenyl)methylene)-, RG-13022, Tyrphostin RG-13022 
A tyrosine kinase inhibitor that selectively inhibits epidermal growth factor receptor, epidermal factor-stimulated HER14 cell proliferation, and… 
National Institutes of Health

Related topics

Related topics

4 relations

Broader (3)

NitrilesPyridinesTyrphostins
Receptor Tyrosine Kinase Inhibition

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2003
2003
Epidermal Growth Factor and Transforming Growth Factor-α Stimulate the Proliferation of Mouse Uterine Stromal Cells
Abstract Growth factors produced in the uterine endometrium are considered to be involved in the proliferation of the mouse… 
2002
2002
Intrapituitary Regulatory System of Mammotrophs in the Mouse
Estrogen stimulates the proliferation of pituitary cells, in particular mammotrophs. The present study was designed to clarify… 
2001
2001
Cell Signaling Pathways Mediating Epidermal Growth Factor Stimulation of Na:K:2Cl Cotransport Activity in Rabbit Corneal Epithelial Cells
Abstract. We characterized the signaling and ion transport pathways that mediate epidermal growth factor receptor physiological… 
1998
1998
Mitogen-activated protein kinase is involved in epidermal-growth-factor-regulated protein phosphorylation in nuclear membranes isolated from JEG-3 human choriocarcinoma cells.
The treatment of highly purified nuclear membranes isolated from JEG-3 human choriocarcinoma cells with epidermal growth factor… 
1996
1996
Tyrosine kinase inhibitor as a novel signal transduction and antiproliferative agent: prostate cancer
1993
1993
Antiproliferative effect of tyrosine kinase inhibitors in epidermal growth factor-stimulated growth of human gastric cancer cells.
AGS human gastric cancer cells were characterized to possess EGF receptors. Scatchard analysis revealed a half saturation… 
Highly Cited
1992
Highly Cited
1992
Inhibition of breast cancer cell growth in vitro by a tyrosine kinase inhibitor.
Human breast cancer cell proliferation is regulated by growth factors that bind to receptors with intrinsic tyrosine kinase (TK… 
Highly Cited
1991
Highly Cited
1991
The antiproliferative effects of tyrosine kinase inhibitors tyrphostins on a human squamous cell carcinoma in vitro and in nude mice.
Many human tumors of epithelial origin contain cells overexpressing the epidermal growth factor (EGF) receptor, and there is… 
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