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RAP1GAP gene

Known as: RAP1GAPII, RAP1 GTPase activating protein, KIAA0474 
 
National Institutes of Health

Papers overview

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Highly Cited
2006
Highly Cited
2006
Identification of a putative tumor suppressor gene Rap1GAP in pancreatic cancer.
Human chromosome 1p35-p36 has long been suspected to harbor a tumor suppressor gene in pancreatic cancer and other tumors. We… Expand
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Highly Cited
2005
Highly Cited
2005
Cyclic AMP Potentiates Vascular Endothelial Cadherin-Mediated Cell-Cell Contact To Enhance Endothelial Barrier Function through an Epac-Rap1 Signaling Pathway
ABSTRACT Cyclic AMP (cAMP) is a well-known intracellular signaling molecule improving barrier function in vascular endothelial… Expand
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Highly Cited
2005
Highly Cited
2005
Cannabinoid Receptor-induced Neurite Outgrowth Is Mediated by Rap1 Activation through Gαo/i-triggered Proteasomal Degradation of Rap1GAPII*
The Gαo/i-coupled CB1 cannabionoid receptor induces neurite outgrowth in Neuro-2A cells. The mechanisms of signaling through Gαo… Expand
Highly Cited
2004
Highly Cited
2004
The GTPase-activating protein Rap1GAP uses a catalytic asparagine
Rap1 is a Ras-like guanine-nucleotide-binding protein (GNBP) that is involved in a variety of signal-transduction processes. It… Expand
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Highly Cited
2002
Highly Cited
2002
Rap-specific GTPase Activating Protein follows an Alternative Mechanism*
Rap1 is a small GTPase that is involved in signal transduction cascades. It is highly homologous to Ras but it is down-regulated… Expand
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Highly Cited
2001
Highly Cited
2001
Rap1 is involved in cell stretching modulation of p38 but not ERK or JNK MAP kinase.
Mechanical force or mechanical stress modulates intracellular signal pathways, including the mitogen-activated protein kinase… Expand
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Highly Cited
2000
Highly Cited
2000
Rap2 as a Slowly Responding Molecular Switch in the Rap1 Signaling Cascade
ABSTRACT Rap2 is a member of the Ras family of GTPases and exhibits 60% identity to Rap1, but the function and regulation of Rap2… Expand
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Highly Cited
1999
Highly Cited
1999
Activation of the ERK/MAPK pathway by an isoform of rap1GAP associated with Gαi
Many receptors for neuropeptides and hormones are coupled with the heterotrimeric Gi protein, which activates the p42/44 mitogen… Expand
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Highly Cited
1999
Highly Cited
1999
Modulation of Rap Activity by Direct Interaction of Gαo with Rap1 GTPase-activating Protein*
We used the yeast two-hybrid system to identify proteins that interact directly with Gαo. Mutant-activated Gαo was used as the… Expand
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Highly Cited
1995
Highly Cited
1995
Identification of Tuberin, the Tuberous Sclerosis-2 Product. TUBERIN POSSESSES SPECIFIC Rap1GAP ACTIVITY (*)
Tuberous sclerosis (TSC) is a human genetic syndrome characterized by the development of benign tumors in a variety of tissues… Expand
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