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RAP1GAP gene

Known as: RAP1GAPII, RAP1 GTPase activating protein, KIAA0474 
 
National Institutes of Health

Papers overview

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Highly Cited
2011
Highly Cited
2011
The tumor suppressor gene rap1GAP is silenced by mir-101-mediated EZH2 overexpression in invasive squamous cell carcinoma
Rap1GAP is a critical tumor suppressor gene that is downregulated in multiple aggressive cancers, such as head and neck squamous… Expand
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Highly Cited
2010
Highly Cited
2010
Downregulation of Rap1GAP through epigenetic silencing and loss of heterozygosity promotes invasion and progression of thyroid tumors.
Thyroid cancer is the most common type of endocrine malignancy, encompassing tumors with various levels of invasive growth and… Expand
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2008
2008
Rap1GAP promotes invasion via induction of matrix metalloproteinase 9 secretion, which is associated with poor survival in low N-stage squamous cell carcinoma.
The objective of the current study was to investigate the effects of Rap1GAP on invasion and progression of head and neck… Expand
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Highly Cited
2005
Highly Cited
2005
Cyclic AMP potentiates vascular endothelial cadherin-mediated cell-cell contact to enhance endothelial barrier function through an Epac-Rap1 signaling pathway.
Cyclic AMP (cAMP) is a well-known intracellular signaling molecule improving barrier function in vascular endothelial cells. Here… Expand
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Highly Cited
2004
Highly Cited
2004
The GTPase-activating protein Rap1GAP uses a catalytic asparagine
Rap1 is a Ras-like guanine-nucleotide-binding protein (GNBP) that is involved in a variety of signal-transduction processes. It… Expand
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2002
2002
Rap-specific GTPase activating protein follows an alternative mechanism.
Rap1 is a small GTPase that is involved in signal transduction cascades. It is highly homologous to Ras but it is down-regulated… Expand
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Highly Cited
2002
Highly Cited
2002
Adaptor protein Crk is required for ephrin-B1-induced membrane ruffling and focal complex assembly of human aortic endothelial cells.
Endothelial cell migration is an essential step in vasculogenesis and angiogenesis, in which receptor tyrosine kinases play a… Expand
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Highly Cited
2001
Highly Cited
2001
Rap1 is involved in cell stretching modulation of p38 but not ERK or JNK MAP kinase.
Mechanical force or mechanical stress modulates intracellular signal pathways, including the mitogen-activated protein kinase… Expand
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Highly Cited
2000
Highly Cited
2000
Rap2 as a slowly responding molecular switch in the Rap1 signaling cascade.
Rap2 is a member of the Ras family of GTPases and exhibits 60% identity to Rap1, but the function and regulation of Rap2 remain… Expand
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Highly Cited
1999
Highly Cited
1999
Modulation of rap activity by direct interaction of Galpha(o) with Rap1 GTPase-activating protein.
We used the yeast two-hybrid system to identify proteins that interact directly with Galpha(o). Mutant-activated Galpha(o) was… Expand
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