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RAP1GAP gene
Known as:
RAP1GAPII
, RAP1 GTPase activating protein
, KIAA0474
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National Institutes of Health
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Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2009
Highly Cited
2009
Role of the small GTPase Rap1 for integrin activity regulation in endothelial cells and angiogenesis.
G. Carmona
,
S. Göttig
,
+8 authors
E. Chavakis
Blood
2009
Corpus ID: 206868671
Ras-associated protein 1 (Rap1), a small GTPase, attracted attention because of its involvement in several aspects of cell…
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Highly Cited
2005
Highly Cited
2005
Cyclic AMP Potentiates Vascular Endothelial Cadherin-Mediated Cell-Cell Contact To Enhance Endothelial Barrier Function through an Epac-Rap1 Signaling Pathway
S. Fukuhara
,
A. Sakurai
,
+6 authors
N. Mochizuki
Molecular and Cellular Biology
2005
Corpus ID: 28390807
ABSTRACT Cyclic AMP (cAMP) is a well-known intracellular signaling molecule improving barrier function in vascular endothelial…
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Highly Cited
2005
Highly Cited
2005
Cannabinoid Receptor-induced Neurite Outgrowth Is Mediated by Rap1 Activation through Gαo/i-triggered Proteasomal Degradation of Rap1GAPII*
J. Jordan
,
J. He
,
+7 authors
R. Iyengar
Journal of Biological Chemistry
2005
Corpus ID: 22445809
The Gαo/i-coupled CB1 cannabionoid receptor induces neurite outgrowth in Neuro-2A cells. The mechanisms of signaling through Gαo…
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Highly Cited
2004
Highly Cited
2004
The GTPase-activating protein Rap1GAP uses a catalytic asparagine
O. Daumke
,
M. Weyand
,
P. Chakrabarti
,
I. Vetter
,
A. Wittinghofer
Nature
2004
Corpus ID: 4426744
Rap1 is a Ras-like guanine-nucleotide-binding protein (GNBP) that is involved in a variety of signal-transduction processes. It…
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Highly Cited
2002
Highly Cited
2002
Rap-specific GTPase Activating Protein follows an Alternative Mechanism*
T. Brinkmann
,
O. Daumke
,
+4 authors
A. Wittinghofer
The Journal of Biological Chemistry
2002
Corpus ID: 10089684
Rap1 is a small GTPase that is involved in signal transduction cascades. It is highly homologous to Ras but it is down-regulated…
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Highly Cited
2001
Highly Cited
2001
Rap1 is involved in cell stretching modulation of p38 but not ERK or JNK MAP kinase.
Y. Sawada
,
K. Nakamura
,
+8 authors
H. Ichijo
Journal of cell science
2001
Corpus ID: 24136188
Mechanical force or mechanical stress modulates intracellular signal pathways, including the mitogen-activated protein kinase…
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Highly Cited
2000
Highly Cited
2000
Rap2 as a Slowly Responding Molecular Switch in the Rap1 Signaling Cascade
Y. Ohba
,
N. Mochizuki
,
+7 authors
M. Matsuda
Molecular and Cellular Biology
2000
Corpus ID: 1886977
ABSTRACT Rap2 is a member of the Ras family of GTPases and exhibits 60% identity to Rap1, but the function and regulation of Rap2…
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Highly Cited
1999
Highly Cited
1999
Activation of the ERK/MAPK pathway by an isoform of rap1GAP associated with Gαi
N. Mochizuki
,
Y. Ohba
,
+6 authors
M. Matsuda
Nature
1999
Corpus ID: 204995543
Many receptors for neuropeptides and hormones are coupled with the heterotrimeric Gi protein, which activates the p42/44 mitogen…
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Highly Cited
1999
Highly Cited
1999
Modulation of Rap Activity by Direct Interaction of Gαo with Rap1 GTPase-activating Protein*
J. Jordan
,
K. Carey
,
P. Stork
,
R. Iyengar
The Journal of Biological Chemistry
1999
Corpus ID: 22437547
We used the yeast two-hybrid system to identify proteins that interact directly with Gαo. Mutant-activated Gαo was used as the…
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Highly Cited
1995
Highly Cited
1995
Identification of Tuberin, the Tuberous Sclerosis-2 Product. TUBERIN POSSESSES SPECIFIC Rap1GAP ACTIVITY (*)
R. Wienecke
,
A. König
,
J. Declue
The Journal of Biological Chemistry
1995
Corpus ID: 43111807
Tuberous sclerosis (TSC) is a human genetic syndrome characterized by the development of benign tumors in a variety of tissues…
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