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Rap1GAP alters leukemia cell differentiation, apoptosis and invasion in vitro.
Results demonstrated that Rap1GAP promoted leukemia cell differentiation and apoptosis, but increased leukemia cell invasion in vitro, may be due to matrix metalloproteinase 9 (MMP9). Expand
Accelerated cellular senescence in myelodysplastic syndrome.
The results of the present study suggested an accelerated cellular senescence occurred in MDS, and the cellularsenescence may be involved in the progression and prognosis of MDS. Expand
BMI1 reprogrammes histone acetylation and enhances c-fos pathway via directly binding to Zmym3 in malignant myeloid progression
- Hong-jie Shen, Zixin Chen, +5 authors Y. Chen
- Biology, Medicine
- Journal of cellular and molecular medicine
- 27 February 2014
The results suggested that BMI1 may reprogramme the histone acetylation profile in multiple genes through either indirect or direct binding effects which probably contributes to the malignant progression of myeloid progenitor cells. Expand
C3aR1 gene overexpressed at initial stage of acute myeloid leukemia-M2 predicting short-term survival
Expression of Dlk1 gene in myelodysplastic syndrome determined by microarray, and its effects on leukemia cells.
- X. Qi, Zixin Chen, Dandan Liu, J. Cen, M. Gu
- Biology, Medicine
- International journal of molecular medicine
- 1 July 2008
The expression of Dlk1 was up-regulated in CD34+ cells from patients with myelodysplastic syndrome by analyzing the gene expression profiles determined by microarray and forced expression increased the mRNA levels of HES1 and inhibited p38 phosphorylation in transfected K562 cells treated with TPA. Expand
Growth and differentiation effects of Homer3 on a leukemia cell line.
The results showed that Homer3 is a novel gene which plays a certain role in the occurrence and development of AML. Expand
Coexistence of p210BCR-ABL and CBFβ-MYH11 fusion genes in myeloid leukemia: A report of 4 cases
The co-expression of p210BCR-ABL and CBFβ-MYH11 fusion genes in myeloid leukemia may be a molecular event occurring not only during the development of CML, but also in AML. Expand
Ras-proximate-1 GTPase-activating protein and Rac2 may play pivotal roles in the initial development of myelodysplastic syndrome.
It is believed that the cadherin-β-catenin-c-myc signaling axis is crucial in the hematopoiesis of HSCs in the early stages of MDS and the two small G proteins, Rap1GAP and Rac2, may act as new molecular markers for the diagnosis of M DS. Expand
The pattern of clonal immunoglobulin and T-cell receptor (Ig/TCR) gene rearrangements in Chinese adult acute lymphoblastic leukemia patients.
Several specialties in the pattern of Ig/TCR gene rearrangements in Chinese adult ALL patients in comparison with those reported for children and adult patients in other countries have been noted, useful for further MRD-RQ-PCR detection and quantification for all patients. Expand
Growth and Differentiation Effects of Homer 3 on a Leukemia Cell Line
The Homer protein family, also known as the family of cytoplasmic scaffolding proteins, which include three subtypes (Homer1, Homer2, Homer3) (Brakeman et al., 1997; Xiao et al., 1998). Homer3 can… Expand