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Matrix Metalloproteinase-2 and -9 Secreted by Leukemic Cells Increase the Permeability of Blood-Brain Barrier by Disrupting Tight Junction Proteins
TLDR
The findings suggest that the degradation of tight junction proteins ZO-1, claudin-5 and occludin by MMP-2 and -9 constitutes an important mechanism in the BBB breakdown which contributes to the invasion of leukemic cells to the CNS in acute leukemia. Expand
Hypermethylation downregulates Runx3 gene expression and its restoration suppresses gastric epithelial cell growth by inducing p27 and caspase3 in human gastric cancer
TLDR
This data indicates that suppression of tumor suppressor genes by aberrant hypermethylation in Runx3 results in down-regulation of cell cycle regulation, differentiation, apoptosis, and malignant transformation in mice bred with Runx2. Expand
Predictive value of high EVI1 expression in AML patients undergoing myeloablative allogeneic hematopoietic stem cell transplantation in first CR
TLDR
The results indicate high EVI1 expression might predict high risk of relapse in AML patients undergoing myeloablative allo-HSCT in CR1, and low EVI 1 expression as an independent prognostic factor favoring LFS. Expand
Overexpressed miR-155 is associated with initial presentation and poor outcome in Chinese pediatric acute myeloid leukemia.
  • L-H Xu, Y. Guo, +6 authors S-Y Hu
  • Medicine
  • European review for medical and pharmacological…
  • 1 December 2015
TLDR
Findings suggested that miR-155 expression cannot only be promising biomarker for the early detection of pediatric AML but also predict poor outcome. Expand
MicroRNA-375 targets the 3-phosphoinositide-dependent protein kinase-1 gene in pancreatic carcinoma
TLDR
Functional assays showed that miR-375 was able to inhibit proliferation and promote apoptosis of the PC cells, suggesting that it may have a potential therapeutic role in the treatment of PC. Expand
Rap1GAP alters leukemia cell differentiation, apoptosis and invasion in vitro.
TLDR
Results demonstrated that Rap1GAP promoted leukemia cell differentiation and apoptosis, but increased leukemia cell invasion in vitro, may be due to matrix metalloproteinase 9 (MMP9). Expand
Identification of novel recurrent CPSF6-RARG fusions in acute myeloid leukemia resembling acute promyelocytic leukemia.
TO THE EDITOR: Retinoic acid receptor γ (RARG) is a member of the nuclear receptor superfamily and shares high homology (90%) with retinoic acid receptor α (RARA) and retinoic acid receptor βExpand
The clinical characteristics and prognostic significance of AID, miR-181b, and miR-155 expression in adult patients with de novo B-cell acute lymphoblastic leukemia
TLDR
Combination of the three molecules are more accurate predictors for unfavorable OS compared with univariate group and provide clinical prognosis of adult de novo B-ALL patients and may refine their molecular risk classification. Expand
Major molecular response prior to allogeneic hematopoietic stem cell transplantation predicts better outcome in adult Philadelphia-positive acute lymphoblastic leukemia in first remission
Major molecular response prior to allogeneic hematopoietic stem cell transplantation predicts better outcome in adult Philadelphia-positive acute lymphoblastic leukemia in first remission
[Prevalence and clinical significance of FLT3 mutations in acute promyelocytic leukemia].
TLDR
FLT3 mutations (FLT 3-ITD or FLT3-TKD) are frequently identified in patients with newly diagnosed APL, both mutations are associated with higher initial WBC and short type PML-RAR alpha isoforms and predicts a poorer prognosis. Expand
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