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RAN GTPase Activating Protein 1

Known as: RANGAP1 protein, human, MGC20266, Ran GTPase activating protein 1, human 
RanGAP1, is a homodimeric 65-kD polypeptide that specifically induces the GTPase activity of RAN, but not of RAS by over 1,000-fold. RanGAP1 is the… 
National Institutes of Health

Related topics

Related topics

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Broader (1)

GTPase-Activating Proteins
Mitotic Spindle Regulation PathwayRACGAP1 geneRANGAP1 geneRANGAP1 wt Allele

Papers overview

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2016
2016
Reconstitution of the Recombinant RanBP2 SUMO E3 Ligase Complex.
One of the few proteins that have SUMO E3 ligase activity is the 358 kDa nucleoporin RanBP2 (Nup358). While small fragments of… 
2014
2014
The Ran GTPase-Activating Protein (RanGAP1) Is Critically Involved in Smooth Muscle Cell Differentiation, Proliferation and Migration following Vascular Injury: Implications for Neointima Formation…
Differentiation and dedifferentiation, accompanied by proliferation play a pivotal role for the phenotypic development of… 
2013
2013
Spectomycin B 1 as a Novel SUMOylation Inhibitor That Directly Binds to SUMO E 2
Conjugation of small ubiquitin-like modifier (SUMO) to protein (SUMOylation) regulates multiple biological systems by changing… 
2012
2012
Supplemental Information The RanBP 2 / RanGAP 1 * SUMO 1 / Ubc 9 Complex Is a Multisubunit SUMO E 3 Ligase
2008
2008
Chronic ethanol exposure induces alterations in the nucleocytoplasmic transport in growing astrocytes
Nucleocytoplasmic transport is a crucial process for cell function. We assessed the general effect of chronic alcohol exposure on… 
2008
2008
Mel-18 interacts with RanGAP1 and inhibits its sumoylation.
2006
2006
SUMO modification through rapamycin-mediated heterodimerization reveals a dual role for Ubc9 in targeting RanGAP1 to nuclear pore complexes.
2004
2004
Structural and Dynamic Independence of Isopeptide-linked RanGAP1 and SUMO-1*
Although sumoylation regulates a diverse and growing number of recognized biological processes, the molecular mechanisms by which… 
1996
1996
Ubiquitous expression and testis-specific alternative polyadenylation of mRNA for the human Ran GTPase activator RanGAP1.
Highly Cited
1994
Highly Cited
1994
A murine homolog of the yeast RNA1 gene is required for postimplantation development.
A gene has been characterized that is required for postimplantation mouse development. The gene, designated fug1, was disrupted… 
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