H. Ponstingl

Publications103
h-index30
Citations4,930
Highly Influential Citations297
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RanGAP1 induces GTPase activity of nuclear Ras-related Ran.
The nuclear Ras-related protein Ran binds guanine nucleotide and is involved in cell cycle regulation. Models of the signal pathway predict Ran to be active as Ran.GTP at the initiation of S phase… Expand
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Catalysis of guanine nucleotide exchange on Ran by the mitotic regulator RCC1
THE product of the gene RCC1 (regulator of chromosome condensation) in a BHK cell line is involved in the control of mitotic events1. Homologous genes have been found in Xenopus 2, Drosophila 3 and… Expand
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Co‐activation of RanGTPase and inhibition of GTP dissociation by Ran‐GTP binding protein RanBP1.
RCC1 (the regulator of chromosome condensation) stimulates guanine nucleotide dissociation on the Ras‐related nuclear protein Ran. Both polypeptides are components of a regulatory pathway that has… Expand
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Human RanGTPase-activating protein RanGAP1 is a homologue of yeast Rna1p involved in mRNA processing and transport.
RanGAP1 is the GTPase activator for the nuclear Ras-related regulatory protein Ran, converting it to the putatively inactive GDP-bound state. Here, we report the amino acid sequence of RanGAP1,… Expand
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Interaction of the nuclear GTP-binding protein Ran with its regulatory proteins RCC1 and RanGAP1.
The guanine nucleotide dissociation and GTPase reactions of Ran, a Ras-related nuclear protein, have been investigated using different fluorescence techniques to determine how these reactions are… Expand
  • 309
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Phosphotransferase and substrate binding mechanism of the cAMP‐dependent protein kinase catalytic subunit from porcine heart as deduced from the 2.0 A structure of the complex with Mn2+ adenylyl…
The crystal structure of the porcine heart catalytic subunit of cAMP‐dependent protein kinase in a ternary complex with the MgATP analogue MnAMP‐PNP and a pseudosubstrate inhibitor peptide,… Expand
  • 336
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Mitotic regulator protein RCC1 is complexed with a nuclear ras-related polypeptide.
We previously reported the purification of a complex of two proteins from human chromatin, consisting of a 47-kDa component called RCC1, which is a negative regulator of mitosis, and a 25-kDa… Expand
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Yrb4p, a yeast Ran–GTP‐binding protein involved in import of ribosomal protein L25 into the nucleus
Gsp1p, the essential yeast Ran homologue, is a key regulator of transport across the nuclear pore complex (NPC). We report the identification of Yrb4p, a novel Gsp1p binding protein. The 123 kDa… Expand
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Human RanBP3, a group of nuclear RanGTP binding proteins 1
A group of novel human Ran‐binding proteins, RanBP3, was identified using the yeast two‐hybrid system via Ran‐mediated interaction with the nucleotide exchange factor RCC1. Several open reading… Expand
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RNA1 Encodes a GTPase-activating Protein Specific for Gsp1p, the Ran/TC4 Homologue of Saccharomyces cerevisiae(*)
Ran/TC4 is a ras-related GTP-binding protein predominantly located in the nucleus. Ran/TC4 is essential for nuclear transport and is involved in mitotic control. In Saccharomyces cerevisiae a gene… Expand
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