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R 59949

Known as: R 59 949, R-59949, R59949 
National Institutes of Health

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2 relations

Broader (2)

PiperidinesQuinazolinones

Papers overview

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2011
2011
Abeta Peptide Toxicity is Reduced After Treatments Decreasing Phosphatidylethanolamine Content in Differentiated Neuroblastoma Cells
We investigated whether the toxicity of oligomeric amyloid-beta peptide (Abeta1-42) upon differentiated human neuroblastoma SH… 
2006
2006
Does diacylglycerol regulate KCNQ channels?
Some ion channels are regulated by inositol phospholipids and by the products of cleavage by phospholipase C (PLC). KCNQ channels… 
Highly Cited
2005
Highly Cited
2005
Role of phospholipase D and diacylglycerol in activating constitutive TRPC‐like cation channels in rabbit ear artery myocytes
Previously we have described a constitutively active Ca2+‐permeable non‐selective cation channel in freshly dispersed rabbit ear… 
2004
2004
Superoxide production at phagosomal cup/phagosome through beta I protein kinase C during Fc gamma R-mediated phagocytosis in microglia.
Protein kinase C (PKC) plays a prominent role in immune signaling. To elucidate the signal transduction in a respiratory burst… 
2003
2003
Monocytic activation of protein tyrosine kinase, protein kinase A and protein kinase C induced by porins isolated from Salmonella enterica serovar Typhimurium.
OBJECTIVES In the present study a monocytic cell line, U937, was used to investigate the possible involvement of protein tyrosine… 
1999
1999
Interleukin-2 Causes an Increase in Saturated/Monounsaturated Phosphatidic Acid Derived from 1,2-Diacylglycerol and 1-O-Alkyl-2-acylglycerol*
Phosphatidic acid generation through activation of diacylglycerol kinase α has been implicated in interleukin-2-dependent T… 
1998
1998
Increased adhesion of peripheral blood neutrophils from patients with localized juvenile periodontitis.
Adhesion of peripheral blood neutrophils from 5 patients with localized juvenile periodontitis (LJP) and age- and gender-matched… 
Highly Cited
1997
Highly Cited
1997
Specific retinal diacylglycerol and protein kinase C beta isoform modulation mimics abnormal retinal hemodynamics in diabetic rats.
PURPOSE Elevation of diacylglycerol (DAG) and protein kinase C (PKC) levels in diabetic vascular tissue is associated with… 
1994
1994
Modulation of nucleocytosolic [Ca2+] gradient in smooth muscle by protein phosphorylation
In resting DDT1MF‐2 smooth muscle cells, the cytosolic free Ca2+ concentration ([Ca2+]c) was higher than the free Ca2… 
1991
1991
The diacylglycerol kinase inhibitor, R59949, potentiates secretion but not increased phosphorylation of a 47 kDalton protein in human platelets.
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