Quinolinic Acids

Ovarian cancer ranks the most lethal among gynecologic neoplasms in women. To develop potential biomarkers for diagnosis, we have… (More)

Glutaric acidemia type I is an inherited metabolic disorder caused by a severe deficiency of the mitochondrial glutaryl-CoA… (More)

Indoleamine 2,3-dioxygenase (IDO) is a tryptophan-catabolizing enzyme that, expressed by different cell types, has regulatory… (More)

To study the complex inter-relationships between inflammatory and apoptotic responses and the kynurenine pathway, we have… (More)

Indoleamine 2,3-dioxygenase (IDO) is a tryptophan-catabolizing enzyme that, expressed by different cell types, has regulatory… (More)

A major route of tryptophan metabolism is via the hepatic and cerebral synthesis of kynurenine, a substance subsequently used by… (More)

Several pieces of evidence suggest a major role for brain macrophages in the overproduction of neuroactive kynurenines, including… (More)

Changes in endogenous somatostatin after quinolinic and kainic acids were investigated by measuring somatostatin-like peaks by in… (More)

We have studied the effects of naturally occurring metabolites of tryptophan, kynurenic and quinolinic acids, on the… (More)

The active (-)-isomers of 2-amino-7-phosphonoheptanoic acid (2-APH) and 2-amino-5-phosphonopentanoic acid (2-APV) have been… (More)