Quinolinic Acids

Systemic inflammation (SI) is involved in the pathogenesis of acute decompensation (AD) and acute-on-chronic liver failure (ACLF… Expand

Previously, we demonstrated that the endogenous glutamate receptor antagonist kynurenic acid dose-dependently and significantly… Expand

Ovarian cancer ranks the most lethal among gynecologic neoplasms in women. To develop potential biomarkers for diagnosis, we have… Expand

Glutaric acidemia type I is an inherited metabolic disorder caused by a severe deficiency of the mitochondrial glutaryl-CoA… Expand

To study the complex inter-relationships between inflammatory and apoptotic responses and the kynurenine pathway, we have… Expand

Several pieces of evidence suggest a major role for brain macrophages in the overproduction of neuroactive kynurenines, including… Expand

Activated glial cells (microglia and astrocytes) are a hallmark of a variety of neurodegenerative diseases. Recent in vitro… Expand

Changes in endogenous somatostatin after quinolinic and kainic acids were investigated by measuring somatostatin-like peaks by in… Expand

In the dinoflagellateGonyaulax polyedra bioluminescence was investigated in constant darkness. Light emission was stimulated… Expand

The active (-)-isomers of 2-amino-7-phosphonoheptanoic acid (2-APH) and 2-amino-5-phosphonopentanoic acid (2-APV) have been… Expand