Quinolinic Acid

Known as: Pyridine-2,3-Dicarboxylic Acid, 2,3-Pyridinedicarboxylic Acid, Quinolinic Acid [Chemical/Ingredient] 
An intermediate product of the kynurenine pathway, which is responsible for the conversion of the amino acid tryptophan into nicotinamide adenine… (More)
National Institutes of Health

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Highly Cited
2005
Highly Cited
2005
There is good evidence that the kynurenine pathway (KP) and one of its end products, quinolinic acid (QUIN) play a role in the… (More)
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Highly Cited
2005
Highly Cited
2005
The present immunohistochemical study provides evidence that the kynurenine pathway is up-regulated in Alzheimer's disease (AD… (More)
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Highly Cited
1996
Highly Cited
1996
Immune activation leads to accumulations of the neurotoxin and kynurenine pathway metabolite quinolinic acid within the central… (More)
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Review
1993
Review
1993
In a little more than 10 years, the kynurenine metabolites of tryptophan have emerged from their former position as biochemical… (More)
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Highly Cited
1992
Highly Cited
1992
Neurological dysfunction, seizures and brain atrophy occur in a broad spectrum of acute and chronic neurological diseases. In… (More)
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Highly Cited
1991
Highly Cited
1991
We previously found a relative sparing of somatostatin and neuropeptide Y neurons 1 week after producing striatal lesions with… (More)
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Highly Cited
1986
Highly Cited
1986
Huntington's disease (HD) is an autosomal dominant neurological disorder characterized by progressive chorea, cognitive… (More)
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Highly Cited
1984
Highly Cited
1984
Kynurenic acid (KYNA) was tested as an antagonist of the neurotoxic and epileptogenic effects of the metabolically related brain… (More)
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Highly Cited
1983
Highly Cited
1983
A current hypothesis links the neuroexcitatory properties of certain acidic amino acids to their ability to cause selective… (More)
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Highly Cited
1982
Highly Cited
1982
Kynurenine and related compounds are endogenous metabolites of tryptophan which have previously been found to be convulsant in… (More)
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