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Dre2, a Conserved Eukaryotic Fe/S Cluster Protein, Functions in Cytosolic Fe/S Protein Biogenesis
TLDR
Dre2 is an essential conserved Fe/S cluster protein implicated in extramitochondrial Fe/s cluster assembly, similar to other components of the so-called CIA (cytoplasmic Fe/ S cluster assembly) pathway although partially localized to the mitochondrial intermembrane space.
Resistance mutations reveal the atovaquone‐binding domain of cytochrome b in malaria parasites
TLDR
Visualization of the resistance‐conferring amino acid positions on the recently solved crystal structure of the vertebrate cytochrome bc1 complex revealed a discrete cavity in which subtle variations in hydrophobicity and volume of the amino acid side‐chains may determine atovaquone‐binding affinity, and thereby selective toxicity.
Adaptation of aerobic respiration to low O2 environments
TLDR
It is proposed that the adaptation of aerobic respiration to low oxygen environments resulted in a concomitant reduction in energy conservation efficiency, with important physiological and ecological consequences.
The RegB/RegA two-component regulatory system controls synthesis of photosynthesis and respiratory electron transfer components in Rhodobacter capsulatus.
TLDR
Here, a combination of DNase I protection and plasmid-based reporter expression studies are used to demonstrate that RegA directly controls synthesis of cytochrome cbb3 and ubiquinol oxidases that function as terminal electron acceptors in a branched respiratory chain.
Roles of the ccoGHIS gene products in the biogenesis of the cbb(3)-type cytochrome c oxidase.
TLDR
Remarkably, the small protein CcoS, with a putative single transmembrane span, is essential for the incorporation of the redox-active prosthetic groups into the cytochrome cbb(3) oxidase.
Reversible redox energy coupling in electron transfer chains
TLDR
This work progressively inactivated individual cofactors comprising cytochrome bc1, and resolved millisecond reversibility in all electron-tunnelling steps and coupled proton exchanges, including charge-separating hydroquinone–quinone catalysis at the Qo site, which shows that redox equilibria are relevant on a catalytic timescale.
Cytochrome c biogenesis: the Ccm system.
TLDR
This work describes emerging functional interactions between the Ccm components categorized into three conserved modules, and presents a mechanistic view of the molecular basis of ubiquitous vinyl-2 approximately Cys(1) and vinyl-4 approximately CYS(2) heme b-apocytochrome thioether bonds in c-type cytochromes.
Novel Rhodobacter capsulatus genes required for the biogenesis of various c‐type cytochromes
TLDR
It is demonstrated for the first time that CcdA homologues are also required for cyt c biogenesis in some Gram‐negative bacteria such as R. capsulatus.
Evolutionary domain fusion expanded the substrate specificity of the transmembrane electron transporter DsbD
TLDR
These findings strongly suggest that, by the acquisition of additional thiol‐redox active domains, DsbD expanded its substrate specificity.
Vibrio cholerae anaerobic induction of virulence gene expression is controlled by thiol-based switches of virulence regulator AphB
  • Z. Liu, M. Yang, +6 authors J. Zhu
  • Biology, Medicine
    Proceedings of the National Academy of Sciences
  • 27 December 2010
TLDR
Under oxygen-limiting conditions, an environment similar to the intestines, V. cholerae virulence genes are highly expressed and anaerobiosis enhances dimerization and activity of AphB, a transcriptional activator that is required for the expression of the key virulence regulator TcpP, which leads to the activation of virulence factor production.
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