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QX-314

Known as: 2-((2,6-dimethylphenyl)amino)-N,N,N-triethyl-2-oxoethanaminium, QX 314 
National Institutes of Health

Related topics

Related topics

3 relations

Broader (2)

LidocaineLocal Anesthetics
analogs & derivatives

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2010
Highly Cited
2010
Selectively targeting pain in the trigeminal system
Highly Cited
2009
Highly Cited
2009
Coapplication of Lidocaine and the Permanently Charged Sodium Channel Blocker QX-314 Produces a Long-lasting Nociceptive Blockade in Rodents
Background:Nociceptive-selective local anesthesia is produced by entry of the permanently charged lidocaine-derivative QX-314… 
2002
2002
Intracellular QX-314 causes depression of membrane potential oscillations in lamprey spinal neurons during fictive locomotion.
Spinal neurons undergo large cyclic membrane potential oscillations during fictive locomotion in lamprey. It was investigated… 
Highly Cited
1998
Highly Cited
1998
Spinal serotonergic receptors mediate facilitation of a nociceptive reflex by subcutaneous formalin injection into the hindpaw in rats
Highly Cited
1997
Highly Cited
1997
The effect of the sodium channel blocker QX-314 on recovery after acute spinal cord injury.
There is evidence that elevated intracellular sodium ([Na+]i) activity potentiates spinal cord injury (SCI) and the hypoxic… 
Highly Cited
1997
Highly Cited
1997
QX-314 inhibits ectopic nerve activity associated with neuropathic pain
Highly Cited
1996
Highly Cited
1996
Tonic activation of presynaptic GABAB receptors on thalamic sensory afferents
1994
1994
Fast sodium action potentials are generated in the distal apical dendrites of rat hippocampal CA1 pyramidal cells
Highly Cited
1989
Highly Cited
1989
EPSPs in rat neocortical neurons in vitro. II. Involvement of N-methyl-D-aspartate receptors in the generation of EPSPs.
1. Intracellular recordings were obtained from neurons in layer II/III of rat frontal cortex. Single-electrode current- and… 
1987
1987
Lophotoxin: Selective blockade of nicotinic transmission in autonomic ganglia by a coral neurotoxin
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