• Publications
  • Influence
GABAA Receptor-Mediated Tonic Inhibition in Thalamic Neurons
Tonic GABAA receptor-mediated inhibition is typically generated byδ subunit-containing extrasynaptic receptors. Because the δ subunit is highly expressed in the thalamus, we tested whetherExpand
  • 274
  • 44
  • PDF
Spontaneous astrocytic Ca2+ oscillations in situ drive NMDAR-mediated neuronal excitation
Astrocytes respond to chemical, electrical and mechanical stimuli with transient increases in intracellular calcium concentration ([Ca2+]i). We now show that astrocytes in situ display intrinsicExpand
  • 537
  • 37
Childhood absence epilepsy: Genes, channels, neurons and networks
Childhood absence epilepsy is an idiopathic, generalized non-convulsive epilepsy with a multifactorial genetic aetiology. Molecular-genetic analyses of affected human families and experimentalExpand
  • 541
  • 32
The slow (<1 Hz) rhythm of non-REM sleep: a dialogue between three cardinal oscillators
The slow (<1 Hz) rhythm, the most important electroencephalogram (EEG) signature of non–rapid eye movement (NREM) sleep, is generally viewed as originating exclusively from neocortical networks. HereExpand
  • 375
  • 32
  • PDF
Are corticothalamic ‘up’ states fragments of wakefulness?
The slow (<1 Hz) oscillation, with its alternating 'up' and 'down' states in individual neurons, is a defining feature of the electroencephalogram (EEG) during slow-wave sleep (SWS). Although thisExpand
  • 291
  • 23
  • PDF
Enhanced tonic GABAA inhibition in typical absence epilepsy
The cellular mechanisms underlying typical absence seizures, which characterize various idiopathic generalized epilepsies, are not fully understood, but impaired γ-aminobutyric acid (GABA)-ergicExpand
  • 302
  • 21
  • PDF
Thalamic Mechanisms of EEG Alpha Rhythms and Their Pathological Implications
  • S. Hughes, V. Crunelli
  • Biology, Medicine
  • The Neuroscientist : a review journal bringing…
  • 1 August 2005
During relaxed wakefulness, the human brain exhibits pronounced rhythmic electrical activity in the α frequency band (8-13 Hz). This activity consists of 3 main components: the classic occipital αExpand
  • 372
  • 19
A role for GABAB receptors in excitation and inhibition of thalamocortical cells
Gamma-aminobutyric acid (GABA) in the thalamus has mainly been associated with the inhibitory modulation of the sensory and cortical flow of information via a 'classical', chloride-dependent, GABAAExpand
  • 325
  • 17
Two inward currents and the transformation of low‐frequency oscillations of rat and cat thalamocortical cells.
1. The contribution of a slow, mixed Na(+)‐K+, inward rectifying current (Ih) and the T‐type Ca2+ current (IT) (that underlies low‐threshold Ca2+ potentials) to the low‐frequency oscillationsExpand
  • 247
  • 17
Low‐frequency oscillatory activities intrinsic to rat and cat thalamocortical cells.
1. Low‐frequency membrane potential oscillations recorded intracellularly from thalamocortical (TC) cells of the rat and cat dorsal lateral geniculate nucleus (dLGN) and of the rat ventrobasalExpand
  • 248
  • 17