GABAA Receptor-Mediated Tonic Inhibition in Thalamic Neurons
- D. Cope, S. Hughes, V. Crunelli
- BiologyJournal of Neuroscience
- 14 December 2005
Tonic GABAA receptor-mediated inhibition is typically generated byδ subunit-containing extrasynaptic receptors. Because the δ subunit is highly expressed in the thalamus, we tested whether…
Spontaneous astrocytic Ca2+ oscillations in situ drive NMDAR-mediated neuronal excitation
- H. Parri, Timothy M. Gould, V. Crunelli
- Biology, PhysicsNature Neuroscience
- 1 August 2001
These findings show that astrocytes in situ can act as a primary source for generating neuronal activity in the mammalian central nervous system.
Childhood absence epilepsy: Genes, channels, neurons and networks
- V. Crunelli, N. Leresche
- Psychology, BiologyNature Reviews Neuroscience
- 1 May 2002
Molecular-genetic analyses of affected human families and experimental models together with neurobiological investigations led to important breakthroughs in the identification of candidate genes and loci, and potential pathophysiological mechanisms for childhood absence epilepsy.
The slow (<1 Hz) rhythm of non-REM sleep: a dialogue between three cardinal oscillators
- V. Crunelli, S. Hughes
- Biology, PsychologyNature Neuroscience
- 2010
It is argued that the full manifestation of this fundamental sleep oscillation in a corticothalamic module requires the dynamic interaction of three cardinal oscillators: one predominantly synaptically based cortical oscillator and two intrinsic, conditional thalamic oscillators.
Enhanced tonic GABAA inhibition in typical absence epilepsy
- D. Cope, G. Di Giovanni, V. Crunelli
- Biology, PsychologyNature Network Boston
- 22 November 2009
It is shown that extrasynaptic GABAA receptor–dependent 'tonic' inhibition is increased in thalamocortical neurons from diverse genetic and pharmacological models of absence seizures, identifying an apparently common cellular pathology in typical absence seizures that may have epileptogenic importance and highlight potential therapeutic targets for the treatment of absence epilepsy.
Are corticothalamic ‘up’ states fragments of wakefulness?
- A. Destexhe, S. Hughes, Michelle Rudolph, V. Crunelli
- BiologyTrends in Neurosciences
- 1 July 2007
Selective T-Type Calcium Channel Block in Thalamic Neurons Reveals Channel Redundancy and Physiological Impact of ITwindow
- Fanny M. Dreyfus, A. Tscherter, N. Leresche
- BiologyJournal of Neuroscience
- 6 January 2010
Using TTA-P2, the first direct demonstration of the presence of a window component of Ca2+ channels in neurons and its contribution to the resting membrane potential of thalamic neurons and to the Up state of their intrinsically generated slow (<1 Hz) oscillation is provided.
A role for GABAB receptors in excitation and inhibition of thalamocortical cells
- V. Crunelli, N. Leresche
- BiologyTrends in Neurosciences
- 31 January 1991
Two inward currents and the transformation of low‐frequency oscillations of rat and cat thalamocortical cells.
- I. Soltesz, S. Lightowler, N. Leresche, D. Jassik-Gerschenfeld, C. Pollard, V. Crunelli
- BiologyJournal of Physiology
- 1 September 1991
In cells showing the pacemaker oscillations it was found that the current developing from the most hyperpolarized potential of an oscillation cycle was an inward relaxation whose time course differed from that of Ih evoked at the same potential.
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