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ERK is sequentially activated in neurons, microglia, and astrocytes by spinal nerve ligation and contributes to mechanical allodynia in this neuropathic pain model
The results suggest that ERK activation in the dorsal horn, as well as in the DRG, mediates pain through different mechanisms operating in different cells at different times, and the sequential activation of ERK in dorsal horn microglia and then in astrocytes might reflect distinct roles for these two subtypes of glia in the temporal evolution of neuropathic pain. Expand
The role of sodium channels in chronic inflammatory and neuropathic pain.
Changes in the expression of neuronal voltage-gated sodium channels may play a key role in the pathogenesis of both chronic neuropathic and chronic inflammatory pain conditions, and drugs that block these channels may have therapeutic efficacy with doses that are far below those that impair nerve impulse propagation or cardiovascular function. Expand
Postthoracotomy pain management problems.
  • P. Gerner
  • Medicine
  • Anesthesiology clinics
  • 1 June 2008
Thoracic epidural analgesia has greatly improved the pain experience and its consequences and has been considered the standard for pain management after thoracotomy, but severe ipsilateral shoulder pain and the prevention of the postthoracotomy pain syndrome remain the most important challenges. Expand
Tricyclic antidepressants as long-acting local anesthetics
The ability of TCAs to pass through various membrane barriers within peripheral nerve trunks is crucial to their local anesthetic efficacy in vivo and is suggested to be more potent than bupivacaine as Na+ channel blockers in Nav1.5 Na+ channels. Expand
Amitriptyline for Prolonged Cutaneous Analgesia in the Rat
Amitriptyline is a longer-acting local anesthetic compared with bupivacaine for cutaneous infiltration and its analgesic effectiveness is significantly enhanced by epinephrine. Expand
Epidemiology and risk factors for perioperative mortality after total hip and knee arthroplasty
The Nationwide Inpatient Sample data from 1998 to 2008 is analyzed and it is demonstrated that the timing of death occurred earlier after TKA when compared to THA, with 50% of fatalities occurring by day 4 versus day 6 of the hospitalization, respectively. Expand
Amitriptyline versus Bupivacaine in Rat Sciatic Nerve Blockade
Findings suggest that amitriptyline could extend its clinical usefulness for peripheral nerve blockade and is a more potent blocker of neuronal Na+ channels than bupivacaine in vivo and in vitro. Expand
Dexmedetomidine Added to Ropivacaine Extends the Duration of Interscalene Brachial Plexus Blocks for Elective Shoulder Surgery When Compared with Ropivacaine Alone: A Single-Center, Prospective,
Dexmedetomidine added to ropivacaine for interscalene blocks increased the duration of the nerve block and improved postoperative pain, and additional efficacy and safety data should encourage further study of peripheral perineural dexmedETomidine in humans. Expand
In Vitro, Inhibition of Mitogen-Activated Protein Kinase Pathways Protects Against Bupivacaine- and Ropivacaine-Induced Neurotoxicity
Given equipotent doses, the neurotoxic potential of lidocaine does not appear to be significantly different from that of bupivacaine and ropvacaine in vitro, but is not selective for any of the investigated subgroups of neurons. Expand
Trends in In-Hospital Major Morbidity and Mortality After Total Joint Arthroplasty: United States 1998–2008
Between 1998 and 2008, trends show increases in several major in-hospital complications after THA and TKA, including pulmonary embolism, sepsis, nonmyocardial infarction cardiac complications, and pneumonia. Expand