Epidemiology, demographics, and pathophysiology of acute spinal cord injury.
Much research over the past 30 to 40 years has focused on elucidating the mechanisms of spinal cord injury, with the complex pathophysiologic processes slowly being unraveled.
Bystander CD8+ T cells are abundant and phenotypically distinct in human tumour infiltrates
It is shown that human lung and colorectal cancer CD8+ TILs can not only be specific for tumour antigens, but also recognize a wide range of epitopes unrelated to cancer (such as those from Epstein–Barr virus, human cytomegalovirus or influenza virus).
Review of the secondary injury theory of acute spinal cord trauma with emphasis on vascular mechanisms.
Evidence is presented to support the theory of secondary injury and the hypothesis that a key mechanism is posttraumatic ischemia with resultant infarction of the spinal cord and that it can be counteracted.
The role of excitotoxicity in secondary mechanisms of spinal cord injury: a review with an emphasis on the implications for white matter degeneration.
Following an initial impact after spinal cord injury (SCI), there is a cascade of downstream events termed 'secondary injury', which culminate in progressive degenerative events in the spinal cord.…
Delayed Transplantation of Adult Neural Precursor Cells Promotes Remyelination and Functional Neurological Recovery after Spinal Cord Injury
- S. Karimi-Abdolrezaee, E. Eftekharpour, Jian Wang, C. Morshead, M. Fehlings
- BiologyJournal of Neuroscience
- 29 March 2006
The results show the presence of a substantial number of surviving NPCs in the injured spinal cord up to 10 weeks after transplantation at the subacute stage of SCI, and that injured rats receiving NPC transplants had improved functional recovery as assessed by the Basso, Beattie, and Bresnahan Locomotor Rating Scale and grid-walk and footprint analyses.
Administration of Methylprednisolone for 24 or 48 Hours or Tirilazad Mesylate for 48 Hours in the Treatment of Acute Spinal Cord Injury: Results of the Third National Acute Spinal Cord Injury…
Patients who received the 48-hour methylprednisolone regimen and who started treatment at 3 to 8 hours were more likely to improve 1 full neurologic grade and show improved motor recovery at 6 weeks and 6 months after injury.
Global prevalence and incidence of traumatic spinal cord injury
- Anoushka Singh, L. Tetreault, S. Kalsi-Ryan, A. Nouri, M. Fehlings
- MedicineClinical Epidemiology
- 23 September 2014
It is demonstrated that the incidence, prevalence, and causation of SCI differs between developing and developed countries and suggests that management and preventative strategies need to be tailored to regional trends.
A New Classification of Thoracolumbar Injuries: The Importance of Injury Morphology, the Integrity of the Posterior Ligamentous Complex, and Neurologic Status
A new proposed classification system for thoracolumbar (TL) spine injuries, including injury severity assessment, designed to assist in clinical management and to facilitate clinical decision-making as a practical alternative to cumbersome classification systems already in use is devised.
Traumatic spinal cord injury
- Christopher S Ahuja, Jefferson R. Wilson, M. Fehlings
- MedicineNature Reviews Disease Primers
- 27 April 2017
Several animal models and complementary behavioural tests of SCI have been developed to mimic this pathological process and form the basis for the development of preclinical and translational neuroprotective and neuroregenerative strategies.
Current status of acute spinal cord injury pathophysiology and emerging therapies: promise on the horizon.
Cell-based strategies including using neural stem cells to remyelinate spared axons are an attractive emerging approach and Regenerative approaches to block inhibitory signals including Nogo and the Rho-Rho-associated kinase pathways have shown promise and are in early stages of clinical evaluation.