Puromycin

Known as: Adenosine, 3'-(alpha-amino-p-methoxyhydrocinnamamido)-3'-deoxy-N,N-dimethyl-, L-, Puromycinum, L-3'-(alpha-Amino-p-methoxyhydrocinnamamido)-3'-deoxy-N,N-dimethyladenosine 
An aminoglycoside antibiotic isolated from the bacterium Streptomyces alboniger. Acting as an analog of the 3' terminal end of aminoacyl-tRNA… (More)
National Institutes of Health

Related topics

Related topics

31 relations

Narrower (15)

2'-deoxy-2'-fluoropuromycin2'-deoxypuromycin4-azidopuromycinCCdApPuro
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Broader (8)

AminesAntibioticsAntibiotics, AntineoplasticAntimetabolites, Antineoplastic
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In BloodPuromycin Hydrochlorideagonistsanalogs & derivatives
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Papers overview

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Highly Cited
2012
Highly Cited
2012
Nuclear translation visualized by ribosome-bound nascent chain puromycylation
Whether protein translation occurs in the nucleus is contentious. To address this question, we developed the ribopuromycylation… (More)
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2006
2006
Combination of calcium ionophore A23187 with puromycin salvages human unfertilized oocytes after ICSI.
OBJECTIVE To determine whether oocyte activation using a combination of calcium ionophore A23187 (A23187) with puromycin could… (More)
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Highly Cited
2005
Highly Cited
2005
Puromycin-based purification of rat brain capillary endothelial cell cultures. Effect on the expression of blood-brain barrier-specific properties.
One of the main difficulties with primary rat brain endothelial cell (RBEC) cultures is obtaining pure cultures. The variation in… (More)
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Review
2004
Review
2004
In-vitro protein evolution by ribosome display and mRNA display.
In-vitro display technologies combine two important advantages for identifying and optimizing ligands by evolutionary strategies… (More)
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2000
2000
Specific bonding of puromycin to full-length protein at the C-terminus.
Puromycin, an analog of the 3' end of aminoacyl-tRNA, causes premature termination of translation by being linked non… (More)
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1996
1996
Estrogenic and antiestrogenic regulation of the half-life of covalently labeled estrogen receptor in MCF-7 breast cancer cells
Effect of estrogens and antiestrogens (AEs) on estrogen receptor (ER) half-life was analyzed in MCF-7 cells by assessing its… (More)
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1992
1992
Parthenogenetic activation of human oocytes by puromycin
Our objective was to obtain parthenogenetic activation of unfertilized human oocytes by puromycin and to try to use this… (More)
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Highly Cited
1980
Highly Cited
1980
Cultured animal cells exposed to amino acid analogues or puromycin rapidly synthesize several polypeptides.
Four major acidic polypeptides, with molecular weights of 88, 72, 71, and 23 thousand, and minor polypeptides with molecular… (More)
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Highly Cited
1967
Highly Cited
1967
AN ARTEFACT IN RADIOAUTOGRAPHY DUE TO BINDING OF FREE AMINO ACIDS TO TISSUES BY FIXATIVES
The binding of labeled free amino acids to liver and to purified protein by commonly used fixatives was investigated… (More)
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Highly Cited
1961
Highly Cited
1961
The dependence of cell-free protein synthesis in E. coli upon naturally occurring or synthetic polyribonucleotides.
template RNA. Other explanations, however, are fully plausible, and it is not possible at this state to rule out alternative… (More)
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