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Neonicotinoid insecticide toxicology: mechanisms of selective action.
TLDR
The neonicotinoids have outstanding potency and systemic action for crop protection against piercing-sucking pests, and they are highly effective for flea control on cats and dogs. Expand
Selective toxicity of neonicotinoids attributable to specificity of insect and mammalian nicotinic receptors.
TLDR
Knowledge reviewed here of the functional architecture and molecular aspects of the insect and mammalian nAChRs and their neonicotinoid-binding site lays the foundation for continued development and use of this new class of safe and effective insecticides. Expand
Fipronil insecticide: novel photochemical desulfinylation with retention of neurotoxicity.
  • D. Hainzl, J. Casida
  • Chemistry, Medicine
  • Proceedings of the National Academy of Sciences…
  • 12 November 1996
TLDR
It is found that fipronil contains a trifluoromethylsulfinyl moiety that is unique among the agrochemicals and therefore presumably important in its outstanding performance, and unexpectedly undergoes a novel and facile photoextrusion reaction on plants upon exposure to sunlight. Expand
Neuroactive insecticides: targets, selectivity, resistance, and secondary effects.
TLDR
Primary toxic effects in mammals from off-target serine hydrolase inhibition include organophosphate-induced delayed neuropathy and disruption of the cannabinoid system. Expand
Mechanisms of selective action of pyrethroid insecticides.
Organophosphate toxicology: safety aspects of nonacetylcholinesterase secondary targets.
Cantharidin-binding protein: identification as protein phosphatase 2A.
  • Y. Li, J. Casida
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences…
  • 15 December 1992
TLDR
Inhibition of PP2A activity may account for the diverse effects and toxicity of cantharidin and its analogs, including the herbicide endothall, in mammals and possibly plants. Expand
Protein phosphatase 2A and its [3H]cantharidin/[3H]endothall thioanhydride binding site. Inhibitor specificity of cantharidin and ATP analogues.
TLDR
CA and three analogues inhibited PP2A and protein phosphatase 1 (PP1) but not PP2B or PP2C, which indicates the potential use of CA analogues as pharmacological probes to investigate cellular processes that are regulated by reversible protein phosphorylation in vivo. Expand
Structural model for gamma-aminobutyric acid receptor noncompetitive antagonist binding: widely diverse structures fit the same site.
TLDR
Six NCAs plus t-butylbicyclophosphorothionate fit the 2' to 9' pore region forming hydrogen bonds with the T6' hydroxyl and hydrophobic interactions with A2', T6', and L9' alkyl substituents, thereby blocking the channel. Expand
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