Purine Nucleoside Phosphorylase, human

Known as: PNP Human, Purine Nucleoside Phosphorylase, NP 
Purine nucleoside phosphorylase (289 aa, ~32 kDa) is encoded by the human PNP gene. This protein plays a role in purine metabolism.
National Institutes of Health

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Carbohydrate MetabolismEnzyme GeneGlycosyltransferase GeneNucleotide Metabolism
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Purine-Nucleoside Phosphorylase

Papers overview

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Highly Cited
2013
Highly Cited
2013
Dimers of mitochondrial ATP synthase form the permeability transition pore.
Here we define the molecular nature of the mitochondrial permeability transition pore (PTP), a key effector of cell death. The… (More)
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Highly Cited
2012
Highly Cited
2012
Cerium dioxide nanoparticles induce apoptosis and autophagy in human peripheral blood monocytes.
Cerium dioxide nanoparticles (CeO(2) NPs) have diversified industrial uses, and novel therapeutic applications are actively being… (More)
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Highly Cited
2010
Highly Cited
2010
Design of curcumin-loaded PLGA nanoparticles formulation with enhanced cellular uptake, and increased bioactivity in vitro and superior bioavailability in vivo.
Curcumin, a yellow pigment present in the spice turmeric (Curcuma longa), has been linked with antioxidant, anti-inflammatory… (More)
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Highly Cited
2008
Highly Cited
2008
In vitro permeation of gold nanoparticles through rat skin and rat intestine: effect of particle size.
Purpose of the present work was to study in vitro permeation of gold nanoparticles (NPs) through isolated rat skin and intestine… (More)
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2005
2005
New catalytic mechanism for human purine nucleoside phosphorylase.
Human purine nucleoside phosphorylase has been submitted to intensive structure-based design of inhibitors, most of them using… (More)
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Highly Cited
1994
Highly Cited
1994
Major species differences between humans and rodents in the susceptibility to pancreatic beta-cell injury.
The ability of beta cells to endure assaults may be relevant in the development of insulin-dependent diabetes mellitus. This… (More)
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Highly Cited
1992
Highly Cited
1992
A continuous spectrophotometric assay for inorganic phosphate and for measuring phosphate release kinetics in biological systems.
  • Martin R Webb
  • Proceedings of the National Academy of Sciences…
  • 1992
A spectrophotometric method for the measurement of inorganic phosphate (P(i)) has been developed by using 2-amino-6-mercapto-7… (More)
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1991
1991
Application of crystallographic and modeling methods in the design of purine nucleoside phosphorylase inhibitors.
Competitive inhibitors of the salvage pathway enzyme purine-nucleoside phosphorylase (purine-nucleoside:orthophosphate… (More)
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1991
1991
Purine nucleoside phosphorylase. Allosteric regulation of a dissociating enzyme.
Purine nucleoside phosphorylase (EC 2.4.2.1) from bovine spleen is a trimeric enzyme that readily dissociates to the monomer… (More)
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Highly Cited
1977
Highly Cited
1977
Lymphospecific toxicity in adenosine deaminase deficiency and purine nucleoside phosphorylase deficiency: possible role of nucleoside kinase(s).
Inherited deficiencies of the enzymes adenosine deaminase (adenosine aminohydrolase; EC 3.5.4.4) and purine nucleoside… (More)
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