Selective toxicity of purine deoxynucleosides for human lymphocyte growth and function.


A role for the enzymes adenosine deaminase (adenosine aminohydrolase, EC and purine-nucleoside phosphorylase (purine-nucleoside:orthophosphate ribosyl-transferase, EC in the functional maturation of lymphoid cells has been revealed by the association of inherited deficiencies of these enzymes and profound immune deficiency. Previous… (More)

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