Purine-Nucleoside Phosphorylase

Known as: Inosine Phosphorylase, Phosphorylases, Purine Nucleoside, Nucleoside Phosphorylases, Purine 
An enzyme that catalyzes the reaction between a purine nucleoside and orthophosphate to form a free purine plus ribose-5-phosphate. EC 2.4.2.1.
National Institutes of Health

Topic mentions per year

Topic mentions per year

1942-2017
010020019422016

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Highly Cited
2012
Highly Cited
2012
Background:Our recent analyses of miRNA expression signatures showed that miR-1 and miR-133a were significantly reduced in… (More)
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2004
2004
BACKGROUND Purine nucleoside phosphorylase (PNP) is the purine salvage enzyme that converts guanosine to guanine and inosine to… (More)
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2002
2002
The findings of the accompanying paper (Németi and Gregus, Toxicol: Sci. 70, 4-12) indicate that the arsenate (AsV) reductase… (More)
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Highly Cited
1999
Highly Cited
1999
The human immunodeficiency virus (HIV) replicates its genome and mutates at exceptionally high rates. As a result, the virus is… (More)
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1997
1997
To probe the catalytic mechanism of human purine nucleoside phosphorylase (PNP), 13 active-site mutants were constructed and… (More)
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1997
1997
X-ray crystallography, molecular modeling, and site-directed mutagenesis were used to delineate the catalytic mechanism of purine… (More)
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Highly Cited
1997
Highly Cited
1997
The immune-mediated graft-versus-leukemia effect is important to prevent relapse after allogeneic progenitor cell transplantation… (More)
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1978
1978
Purine nucleoside phosphorylase has been purified about 7,300-fold and crystallized from human erythrocytes (mol wt 81,000). The… (More)
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Highly Cited
1977
Highly Cited
1977
Inherited deficiencies of the enzymes adenosine deaminase (adenosine aminohydrolase; EC 3.5.4.4) and purine nucleoside… (More)
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Highly Cited
1975
Highly Cited
1975
A 5-year-old girl with a history of recurrent infection and anaemia has no measurable purine nucleoside phosphorylase (N.P… (More)
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