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Proto-Oncogene Proteins B-raf

Known as: Proto-Oncogene Proteins B-raf [Chemical/Ingredient], BRAF Kinases, Protein B-raf, Proto-Oncogene 
A raf kinase subclass found at high levels in neuronal tissue. The B-raf Kinases are MAP kinase kinase kinases that have specificity for MAP KINASE… 
National Institutes of Health

Related topics

Related topics

10 relations

Narrower (1)

BRAF protein, human
In BloodProcess of secretionantagonists & inhibitorsaspects of radiation effects

Broader (2)

Protein-Serine-Threonine KinasesProto-Oncogene Proteins

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2008
Highly Cited
2008
Akt3 and mutant V600E B-Raf cooperate to promote early melanoma development.
B-Raf is the most mutated gene in melanoma; however, the mechanism through which it promotes early melanomas remains uncertain… 
Review
2006
Review
2006
Role of Raf kinase in cancer: therapeutic potential of targeting the Raf/MEK/ERK signal transduction pathway.
Improvements in our understanding of the molecular basis of cancer have led to the clinical development of protein kinase… 
Highly Cited
2004
Highly Cited
2004
Calcium Restriction Allows cAMP Activation of the B-Raf/ERK Pathway, Switching Cells to a cAMP-dependent Growth-stimulated Phenotype*
cAMP can be either mitogenic or anti-mitogenic, depending on the cell type. We demonstrated previously that cAMP inhibited the… 
Highly Cited
2004
Highly Cited
2004
Inactivation of Icmt inhibits transformation by oncogenic K-Ras and B-Raf.
Isoprenylcysteine carboxyl methyltransferase (Icmt) methylates the carboxyl-terminal isoprenylcysteine of CAAX proteins (e.g… 
Highly Cited
2003
Highly Cited
2003
Functional analysis of mutations within the kinase activation segment of B-Raf in human colorectal tumors.
Mutations in the B-Raf gene have been reported in a number of human cancers, including colorectal carcinoma. More than 80% of the… 
Highly Cited
2000
Highly Cited
2000
Negative regulation of the serine/threonine kinase B-Raf by Akt.
B-Raf contains multiple Akt consensus sites located within its amino-terminal regulatory domain. One site, Ser(364), is conserved… 
Highly Cited
1999
Highly Cited
1999
B-Raf Inhibits Programmed Cell Death Downstream of Cytochrome c Release from Mitochondria by Activating the MEK/Erk Pathway
ABSTRACT Growth factor-dependent kinases, such as phosphatidylinositol 3-kinase (PI 3-kinase) and Raf kinases, have been… 
Highly Cited
1995
Highly Cited
1995
Conditionally oncogenic forms of the A-Raf and B-Raf protein kinases display different biological and biochemical properties in NIH 3T3 cells
The protein kinase domains of mouse A-Raf and B-Raf were expressed as fusion proteins with the hormone binding domain of the… 
Highly Cited
1995
Highly Cited
1995
Rapid induction of heparin-binding epidermal growth factor/diphtheria toxin receptor expression by Raf and Ras oncogenes.
We have used differential display PCR to search for mRNAs induced by delta Raf-1:ER, an estradiol-dependent form of Raf-1 kinase… 
Highly Cited
1995
Highly Cited
1995
Differential regulation of Raf-1 and B-Raf and Ras-dependent activation of mitogen-activated protein kinase by cyclic AMP in PC12 cells
Growth factor stimulation of the mitogen-activated protein (MAP) kinase pathway in fibroblasts is inhibited by cyclic AMP (cAMP… 
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