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Mammalian Ras interacts directly with the serine/threonine kinase raf
We have identified proteins that interact with H-Ras using a two hybrid system screen of a mouse cDNA library. Approximately 50% of the clones identified encoded portions of the c-Raf and A-RafExpand
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Polycistronic RNA polymerase II expression vectors for RNA interference based on BIC/miR-155
Vector-based RNA interference (RNAi) has emerged as a valuable tool for analysis of gene function. We have developed new RNA polymerase II expression vectors for RNAi, designated SIBR vectors, basedExpand
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Negative regulation of the serine/threonine kinase B-Raf by Akt.
B-Raf contains multiple Akt consensus sites located within its amino-terminal regulatory domain. One site, Ser(364), is conserved with c-Raf but two additional sites, Ser(428) and Thr(439), areExpand
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Ras-Raf interaction: two-hybrid analysis.
The identification of proteins mediating Ras effects, such as the serine/threonine kinases of the Raf family, has advanced our understanding of how signals are transmitted from the extracellularExpand
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Increasing Complexity of the Ras Signaling Pathway*
  • A. Vojtek, C. Der
  • Biology, Medicine
  • The Journal of Biological Chemistry
  • 7 August 1998
Ras is a key regulator of cell growth in all eukaryotic cells. Genetic, biochemical, and molecular studies in Caenorhabditis elegans, Drosophila, and mammalian cells have positioned Ras centrally inExpand
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A single amino acid change in Raf-1 inhibits Ras binding and alters Raf-1 function.
Ras and Raf-1 are key proteins involved in the transmission of developmental and proliferative signals generated by receptor and nonreceptor tyrosine kinases. Genetic and biochemical studiesExpand
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Rho family members: Activators of MAP kinase cascades
Low molecularweight GTP-binding proteins are molecular switches that control a diverse array of biological processes (Bourne et al., 1991). When bound to GTP, these proteins transduce signals toExpand
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Retinal injury, growth factors, and cytokines converge on β-catenin and pStat3 signaling to stimulate retina regeneration.
Müller glia (MG) in the zebrafish retina respond to retinal injury by generating multipotent progenitors for retinal repair. Here, we show that Insulin, Igf-1, and fibroblast growth factor (FGF)Expand
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Fgd1, the Cdc42 GEF responsible for Faciogenital Dysplasia, directly interacts with cortactin and mAbp1 to modulate cell shape.
FGD1 mutations result in Faciogenital Dysplasia (FGDY), an X-linked human disease that affects skeletal formation and embryonic morphogenesis. FGD1 and Fgd1, the mouse FGD1 ortholog, encode guanineExpand
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Serum- and Glucocorticoid-inducible Kinase SGK Phosphorylates and Negatively Regulates B-Raf*
Phosphorylation can both positively and negatively regulate activity of the Raf kinases. Akt has been shown to phosphorylate and inhibit C-Raf activity. We have recently reported that Akt negativelyExpand
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