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Proto-Oncogene Protein pp60 (c-src)

Known as: Protein src, Proto-Oncogene, pp60 c src, src Proto Oncogene Product 
Membrane-associated tyrosine-specific kinases encoded by the c-src genes. They have an important role in cellular growth control. Truncation of… 
National Institutes of Health

Related topics

Related topics

13 relations
In BloodProcess of secretionSRC geneantagonists & inhibitors

Narrower (4)

MATK protein, humanMatk protein, mouseProto-Oncogene Tyrosine-Protein Kinase Src, humanlyn protein-tyrosine kinase

Papers overview

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Highly Cited
2006
Highly Cited
2006
TGF-beta 1-induced PAI-1 expression is E box/USF-dependent and requires EGFR signaling.
Highly Cited
2003
Highly Cited
2003
Nucleophosmin-anaplastic lymphoma kinase of anaplastic large-cell lymphoma recruits, activates, and uses pp60c-src to mediate its mitogenicity.
Anaplastic large-cell lymphomas (ALCLs) are lymphomas of T or null phenotype often associated with a chromosomal translocation, t… 
Highly Cited
2002
Highly Cited
2002
Src Family Kinases Phosphorylate Protein Kinase C δ on Tyrosine Residues and Modify the Neoplastic Phenotype of Skin Keratinocytes*
Protein kinase C δ (PKC δ) is tyrosine-phosphorylated and catalytically inactive in mouse keratinocytes transformed by a ras… 
Review
2000
Review
2000
Threonine Phosphorylation of the β3 Integrin Cytoplasmic Tail, at a Site Recognized by PDK1 and Akt/PKB in Vitro, Regulates Shc Binding*
The mechanism of outside-in signaling by integrins parallels that for growth factor receptors. In both pathways, phosphorylation… 
Highly Cited
1999
Highly Cited
1999
Identification of phosphorylation sites in the PKD1-encoded protein C-terminal domain.
The PKD1-encoded protein, "polycystin-1", has a large N-terminal extracellular portion, multiple transmembrane domains, and a… 
1996
1996
Tight‐binding inhibitory sequences against pp60 c−src identified using a random 15‐amino‐acid peptide library
Highly Cited
1994
Highly Cited
1994
Identification of phosphorylated peptides from complex mixtures using negative-ion orifice-potential stepping and capillary liquid chromatography/electrospray ionization mass spectrometry.
A rapid method for identifying and characterizing sites of phosphorylation of peptides and proteins is described. High… 
Highly Cited
1993
Highly Cited
1993
Translocation of pp60c-src from the plasma membrane to the cytosol after stimulation by platelet-derived growth factor.
Highly Cited
1990
Highly Cited
1990
Synaptophysin: a substrate for the protein tyrosine kinase pp60c-src in intact synaptic vesicles.
Expression of pp60c-src, the first well defined proto-oncogene product, is developmentally regulated and tissue-specific, with… 
Highly Cited
1985
Highly Cited
1985
A mutation at the ATP-binding site of pp60v-src abolishes kinase activity, transformation, and tumorigenicity
We constructed a mutant, called RSV-SF2, at the ATP-binding site of pp60v-src. In this mutant, lysine-295 is replaced with… 
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