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Proto-Oncogene Protein c-kit

Known as: Proto-Oncogene Proteins c-kit [Chemical/Ingredient], c-kit, p145, c kit Receptor 
A protein-tyrosine kinase receptor that is specific for STEM CELL FACTOR. This interaction is crucial for the development of hematopoietic, gonadal… 
National Institutes of Health

Related topics

Related topics

21 relations
C-KIT GeneCD117 Ag:PrThr:Pt:Bld:Ord:Immune stainCD117 Ag:PrThr:Pt:Bone mar:Ord:Immune stainCD117 Ag:PrThr:Pt:Tiss:Ord:Immune stain

Narrower (2)

Mast/Stem Cell Growth Factor Receptor Kit, humanxkrk1 protein, Xenopus

Broader (2)

Protein Tyrosine KinaseProto-Oncogenes

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2005
Highly Cited
2005
Imatinib mesylate lacks activity in small cell lung carcinoma expressing c‐kit protein: A phase II clinical trial
Highly Cited
2002
Highly Cited
2002
Transcriptional profiling reveals regulated genes in the hippocampus during memory formation
Transcriptional profiling (TP) offers a powerful approach to identify genes activated during memory formation and, by inference… 
Highly Cited
1996
Highly Cited
1996
Studies of W mutant mice provide evidence for alternate mechanisms capable of activating hematopoietic stem cells.
Previous studies have suggested that Steel factor (SF) can influence the behavior of many types of hematopoietic progenitor cells… 
Highly Cited
1995
Highly Cited
1995
Identification and characterization of a soluble c-kit receptor produced by human hematopoietic cell lines.
Stem cell factor (SCF) triggers cell growth by binding to cell surface c-kit receptors. Soluble forms of several cytokine… 
Highly Cited
1994
Highly Cited
1994
Human umbilical vein endothelial cells display high-affinity c-kit receptors and produce a soluble form of the c-kit receptor.
Stem cell factor (SCF) is a hematopoietic growth factor produced by fibroblasts and endothelial cells that stimulates the growth… 
Highly Cited
1994
Highly Cited
1994
Expression of the c-kit proto-oncogene in myeloproliferative disorders and myelodysplastic syndromes.
The c-kit proto-oncogene is the receptor gene for the stem cell growth factor. Little is known about the distribution and role of… 
Highly Cited
1993
Highly Cited
1993
c-myc expression correlates with suppression of c-kit protooncogene expression in small cell lung cancer cell lines.
Highly Cited
1993
Highly Cited
1993
Possible involvement of c-kit receptor and its ligand in increase of mast cells in neurofibroma tissues.
Many mast cells are present in the tumor tissues of neurofibromatosis 1. We investigated the mechanism of the mast cell increase… 
Highly Cited
1992
Highly Cited
1992
Interaction of human bone marrow fibroblasts with megakaryocytes: role of the c-kit ligand.
Human kit ligand (KL), also known as stem cell factor (SCF), steel factor, or mast cell growth factor, is a recently identified… 
Highly Cited
1991
Highly Cited
1991
The c-fms gene complements the mitogenic defect in mast cells derived from mutant W mice but not mi (microphthalmia) mice.
Mutations at three loci in the mouse--W, Steel Sl), and microphthalmia (mi)--can lead to a deficiency in melanocytes and mast… 
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