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Protein Kinase C-delta

Known as: Serine-Threonine Kinase, PKC-delta, PKC-delta Serine-Threonine Kinase, PKC delta Serine Threonine Kinase 
A ubiquitously expressed protein kinase that is involved in a variety of cellular SIGNAL PATHWAYS. Its activity is regulated by a variety of… 
National Institutes of Health

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Related topics

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In BloodPRKCD geneProcess of secretionantagonists & inhibitors

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Prkcd protein, mousePrkcd protein, rat

Papers overview

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Highly Cited
2009
Highly Cited
2009
Protein Kinase Cδ Supports Survival of MDA-MB-231 Breast Cancer Cells by Suppressing the ERK1/2 Pathway*
Mechanisms that mediate apoptosis resistance are attractive therapeutic targets for cancer. Protein kinase Cδ (PKCδ) is… 
2007
2007
Protein Kinase Cϵ (PKCϵ) and Src Control PKCδ Activation Loop Phosphorylation in Cardiomyocytes*
Protein kinase Cδ (PKCδ) is unusual among AGC kinases in that it does not require activation loop (Thr505) phosphorylation for… 
2007
2007
Phosphorylation of adducin by protein kinase Cdelta promotes cell motility.
Protein kinase Cdelta (PKCdelta) has been implicated to play a crucial role in cell proliferation, differentiation and apoptosis… 
Highly Cited
2005
Highly Cited
2005
Nanomolar concentration of NSC606985, a camptothecin analog, induces leukemic-cell apoptosis through protein kinase Cdelta-dependent mechanisms.
As a promising new class of anticancer drugs, camptothecins have advanced to the forefront of several areas of therapeutic and… 
2005
2005
Interferon-alpha-induced expression of phospholipid scramblase 1 through STAT1 requires the sequential activation of protein kinase Cdelta and JNK.
Phospholipid scramblase 1 (PLSCR1), a calcium-binding protein that either inserts into the plasma membrane or binds to genomic… 
2002
2002
Activation of SAPK/JNK signaling by protein kinase Cdelta in response to DNA damage.
The cellular response to genotoxic stress includes activation of protein kinase Cdelta (PKCdelta). The functional role of… 
2002
2002
Pathways of Induction of Peroxiredoxin I Expression in Osteoblasts
Peroxiredoxin I (Prx I) is an oxidative stress-inducible antioxidant protein with thioredoxin peroxidase activity. Here we report… 
Highly Cited
2000
Highly Cited
2000
Functional interaction between RAFT1/FRAP/mTOR and protein kinase Cδ in the regulation of cap‐dependent initiation of translation
Hormones and growth factors induce protein translation in part by phosphorylation of the eukaryotic initiation factor 4E (eIF4E… 
1998
1998
Stimulation of melanogenesis in a human melanoma cell line by bistratene A.
1997
1997
The Catalytic Domain of Protein Kinase Cδ Confers Protection from Down-regulation Induced by Bryostatin 1*
Bryostatin 1 (Bryo) has been shown to induce biphasic dose-response curves for down-regulating protein kinase Cδ (PKCδ) as well… 
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