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Neutrophils Are a Key Component of the Antitumor Efficacy of Topical Chemotherapy with Ingenol-3-Angelate1
- Jodie M Challacombe, A. Suhrbier, S. Ogbourne
- Biology, MedicineThe Journal of Immunology
- 1 December 2006
Evidence that neutrophils are required to prevent relapse of skin tumors following topical treatment with a new anticancer agent, ingenol-3-angelate (PEP005), and a central role for neutrophil-mediated ADCC in preventing relapse are suggested, illustrating that neutophils can be induced to mediate important anticancer activity with specific chemotherapeutic agents.
Melanocortin-1 receptor genotype is a risk factor for basal and squamous cell carcinoma.
The association persisted, confirming that presence of at least one variant allele remains informative in terms of predicting risk for developing a solar-induced skin lesion beyond that information wained through observation of pigmentation phenotype.
Histone deacetylase inhibitors trigger a G2 checkpoint in normal cells that is defective in tumor cells.
- L. Qiu, A. Burgess, D. Fairlie, H. Leonard, P. Parsons, B. Gabrielli
- BiologyMolecular biology of the cell
- 1 June 2000
It is reported that histone deacetylase inhibitors, in particular azelaic bishydroxamic acid, triggers a G2 phase cell cycle checkpoint response in normal human cells, and this checkpoint is defective in a range of tumor cell lines.
Head and neck cancer: past, present and future
- D. Chin, G. Boyle, S. Porceddu, D. Theile, P. Parsons, W. Coman
- MedicineExpert review of anticancer therapy
- 1 July 2006
In this review, the primary focus is on head and neck squamous cell carcinoma arising from the mucosal lining of the oral cavity and pharynx, excluding nasopharyngeal cancer.
Nuclear targeting of the growth hormone receptor results in dysregulation of cell proliferation and tumorigenesis
- B. Conway-Campbell, Jong Wei Wooh, M. Waters
- Biology, MedicineProceedings of the National Academy of Sciences
- 14 August 2007
It is concluded that aberrant nuclear localization of GHR is a marker of high proliferative status and is sufficient to induce tumorigenesis and tumor progression.
Antitumor activity of 3-ingenyl angelate: plasma membrane and mitochondrial disruption and necrotic cell death.
PEP005 emerges as a new topical anti-skin cancer agent that has a novel mode of action involving plasma membrane and mitochondrial disruption and primary necrosis, ultimately resulting in an excellent cosmetic outcome.
Chromosomal structure of the human TYRP1 and TYRP2 loci and comparison of the tyrosinase-related protein gene family.
Examination of the position of other intron junctions suggests that TYRP1 was derived from a TYR duplication and then was itself duplicated to give rise to the TYRP2 gene, which suggests that at least some of the introns within the TYR,TYRP1, and TY RP2 coding regions were gained after duplication and that intron slippage is unlikely to have occurred.
Characterization of the Melanoma miRNAome by Deep Sequencing
A comprehensive analysis of the miRNAome in a diverse range of pigment cells including melanoblasts, melanocytes, congenital nevocytes, acral, mucosal, cutaneous and uveal melanoma cells revealed 539 known mature and mature-star sequences along with the prediction of 279 novel miRNA candidates.
Mechanism of melphalan resistance developed in vitro in human melanoma cells.
Melphalan resistance developed previously in a human melanoma cell line (MM253) could not be further increased and evidence suggests that the cross-linking events and that developed resistance arises from decreased susceptibility to DNA to this damage.
Histone deacetylase inhibitors and malignant melanoma.
Of the many genes regulated by HDAC inhibitors, induction of p21(WAF1/Cip1) is the most consistent finding and is associated with G(1) or G(2) phase blocks, and some melanoma cell lines appear to lack an HDAC inhibitor-specific G( 2) checkpoint and viability is thus compromised by dividing with inappropriately-modified chromatin.