Interferon-alpha-induced expression of phospholipid scramblase 1 through STAT1 requires the sequential activation of protein kinase Cdelta and JNK.

@article{Zhao2005InterferonalphainducedEO,
  title={Interferon-alpha-induced expression of phospholipid scramblase 1 through STAT1 requires the sequential activation of protein kinase Cdelta and JNK.},
  author={Ke-Wen Zhao and Dong Li and Qian Zhao and Ying Huang and Robert H. Silverman and Peter J. Sims and Guo-Qiang Chen},
  journal={The Journal of biological chemistry},
  year={2005},
  volume={280 52},
  pages={42707-14}
}
Phospholipid scramblase 1 (PLSCR1), a calcium-binding protein that either inserts into the plasma membrane or binds to genomic DNA in the nucleus, has been shown to contribute to the cell proliferation, differentiation, and apoptosis as well as antiviral activity of interferon (IFN). The expression of PLSCR1 protein is also known to be markedly increased in response to IFN and to some differentiation inducing agents such as all-trans retinoic acid, but the precise mechanisms of this response… CONTINUE READING

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