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Protein Kinase C Alpha

Known as: Protein Kinase C-alpha [Chemical/Ingredient], PKC alpha Serine Threonine Kinase, Protein Kinase C-alpha 
A cytoplasmic serine threonine kinase involved in regulating CELL DIFFERENTIATION and CELLULAR PROLIFERATION. Overexpression of this enzyme has been… 
National Institutes of Health

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In BloodPRKCA genePRKCA wt AlleleProcess of secretion

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PRKCA protein, human

Papers overview

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2012
2012
High glucose increases nitric oxide generation in lipopolysaccharide-activated macrophages by enhancing activity of protein kinase C-α/δ and NF-κB
Although several mechanisms by which hyperglycemia modulate inflammation have been proposed, it remains unclear how hyperglycemia… 
2007
2007
Mechanism of inhibition of sequestration of protein kinase C alpha/betaII by ceramide. Roles of ceramide-activated protein phosphatases and phosphorylation/dephosphorylation of protein kinase C alpha…
Sustained activation of protein kinase C (PKC) isoenzymes alpha and betaII leads to their translocation to a perinuclear region… 
2003
2003
Assignment of amide proton signals by combined evaluation of HN, NN and HNCA MAS-NMR correlation spectra
In this paper, we present a strategy for the 1HN resonance assignment in solid-state magic-angle spinning (MAS) NMR, using the… 
2003
2003
Protein kinase C alpha associates with phospholipase D1 and enhances basal phospholipase D activity in a protein phosphorylation-independent manner in human melanoma cells.
It is well known that phospholipase D plays a crucial part in the signal transduction of many types of cells, and is activated by… 
2002
2002
Nitrogen inversion in cyclic amines and the bicyclic effect.
The hitherto unsolved problem of the origin of the unusually high nitrogen inversion-rotation (NIR) barriers in 7-azabicyclo[2.2… 
2001
2001
Sterically hindered C(alpha, alpha)-disubstituted alpha-amino acids: synthesis from alpha-nitroacetate and incorporation into peptides.
The preparation of sterically hindered and polyfunctional C(alpha,alpha)-disubstituted alpha-amino acids (alpha alpha AAs) via… 
1997
1997
Phosphorylation events mediated by protein kinase C alpha and epsilon participate in regulation of tau steady-state levels and generation of certain "Alzheimer-like" phospho-epitopes.
Hyperactivation of protein kinase C (PKC) in intact neuroblastoma cells by several methods increases site-specific tau… 
1995
1995
Activation of protein kinase C alpha inhibits signaling by members of the insulin receptor family.
Stimulation of the activity of protein kinase C by pretreatment of cells with phorbol esters was tested for its ability to… 
1995
1995
Integrin-linked tyrosine phosphorylation increases membrane association of protein kinase C alpha in pancreatic acinar cells.
Ligation of beta 1 integrin receptors resulted in increased tyrosine phosphorylation of at least five proteins (Mrest = 110, 85… 
1994
1994
Identification of serines‐1035/1037 in the kinase domain of the insulin receptor as protein kinase Cα mediated phosphorylation sites
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