Chai-yi Lin

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Reactive oxygen species (ROS) plays a critical role in the regulation of NLRP3 inflammasome activation. However, the ROS-mediated signaling pathways controlling NLRP3 inflammasome activation are not well defined. Using lipopolysaccharide (LPS) and adenosine triphosphate (ATP) activated murine macrophages as the testing model, cytokine release and protein(More)
AIM To investigate the role of hTERT gene expression and AP-2alpha in n-butylidenephthalide (n-BP)-induced apoptosis in A549 lung cancer cells. METHODS Viability of A549 cells was measured by MTT assay. Protein expression was determined by Western blot. Telomerase activity was measured using the modified telomere repeat amplification protocol (TRAP)(More)
Although several mechanisms by which hyperglycemia modulate inflammation have been proposed, it remains unclear how hyperglycemia regulates inflammation induced by lipopolysaccharide (LPS). We hypothesized that hyperglycemia might interplay with LPS to modulate the generation of an inflammatory mediator. RAW 264.7 macrophages cultured in medium containing(More)
Klebsiella pneumoniae (strain 43816, K2 serotype) induces interleukin-1β (IL-1β) secretion, but neither the bacterial factor triggering the activation of these inflammasome-dependent responses nor whether they are mediated by NLRP3 or NLRC4 is known. In this study, we identified a capsular polysaccharide (K1-CPS) in K. pneumoniae (NTUH-K2044, K1 serotype),(More)
Bamboo vinegar (BV), a natural liquid derived from the condensation produced during bamboo charcoal production, has been used in agriculture and as a food additive, but its application to immune modulation has not been reported. Here, we demonstrated that BV has anti-inflammatory activities both in vitro and in vivo. BV reduced inducible nitric oxide(More)
A novel photobioreactor was developed with a total volume of 30 m(3) which required merely 100 m(3) of land footprint. The bioreactor was capable of utilizing CO(2) in the flue gas of a power plant as the carbon source for the growth of a freshwater alga, Spirulina platensis, mitigating the greenhouse effect caused by the same amount of CO(2) discharge.(More)
This study analyzed the hydrodistilled essential oils in the leaves and twigs of Litsea akoensis to determine composition and yield. Seventy-one and 40 compounds were identified in the leaf and twig oils, respectively. The main components of leaf oil were limonene (18.5%), thymol (10.1%), p-cymene (9.6%), beta-caryophyllene (8.9%), and carvacrol (8.2%). The(More)
The hydrodistilled leaf essential oil of Machilus philippinensis was analyzed to determine its composition and yield. Seventy compounds were identified, the main ones being beta-caryophyllene (13.6%), alpha-pinene (12.0%), alpha-cadinol (7.4%), cis-ocimene (7.0%), spathulenol (5.6%), (E)-nerolidol (5.3%), tau-cadinol (4.8%) and beta-pinene (4.5%).(More)
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