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Protein Farnesylation

Known as: C-terminal protein farnesylation, Farnesylation, Protein, protein amino acid farnesylation 
OBSOLETE. The covalent or non-covalent attachment of a farnesyl group to the carboxy terminus of a protein. [GOC:jl]
National Institutes of Health

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Broader (1)

Protein Prenylation

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2017
2017
Burn-induced muscle metabolic derangements and mitochondrial dysfunction are associated with activation of HIF-1α and mTORC1: Role of protein farnesylation
Metabolic derangements are a clinically significant complication of major trauma (e.g., burn injury) and include various aspects… 
Highly Cited
2010
Highly Cited
2010
Protein Farnesylation–Dependent Raf/Extracellular Signal–Related Kinase Signaling Links to Cytoskeletal Remodeling to Facilitate Glucose-Induced Insulin Secretion in Pancreatic β-Cells
OBJECTIVE Posttranslational prenylation (e.g., farnesylation) of small G-proteins is felt to be requisite for cytoskeletal… 
2010
2010
Blocking protein farnesylation improves nuclear shape abnormalities in keratinocytes of mice expressing the prelamin A variant in Hutchinson-Gilford progeria syndrome
Hutchinson-Gilford progeria syndrome (HGPS) is an accelerated aging disorder caused by mutations in LMNA leading to expression of… 
2007
2007
Inhibition of Protein Farnesylation Arrests Adipogenesis and Affects PPARγ Expression and Activation in Differentiating Mesenchymal Stem Cells
Protein farnesylation is required for the activation of multiple proteins involved in cell differentiation and function. In white… 
2006
2006
In vitro and in vivo analysis of the role of Pex19p farnesylation and Pex14p phosphorylation in peroxisome biogenesis
2005
2005
Tools to analyze protein farnesylation in cells.
Farnesylation of proteins is catalyzed by protein farnesyl transferase (FTase) and is obligatory for the function of the… 
2004
2004
Getting a handle on protein farnesylation
A new technique based on the Staudinger ligation has enabled researchers to conduct a broad analysis of cellular targets of… 
2003
2003
Phase I I a nd P harmacodynamic S tudy o f t he Farnesyltransfer ase I nhibitor R 115777 a s I nitial T herapy i n Patients W ith M etastatic P ancreatic A denocarcinoma
Purpose: R115777 is a selective nonpeptidomimetic inhibitor of farnesyltransferase (FTase), one of several enzymes responsible… 
1999
1999
Characterization of the Ras homologue of Schistosoma mansoni.
Highly Cited
1998
Highly Cited
1998
Lovastatin inhibits proliferation of pancreatic cancer cell lines with mutant as well as with wild-type K-ras oncogene but has different effects on protein phosphorylation and induction of apoptosis.
Besides its pharmacological effect on cholesterol biosynthesis, lovastatin inhibits p21ras proteins by substrate depletion for… 
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