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Protein Farnesylation

Known as: C-terminal protein farnesylation, Farnesylation, Protein, protein amino acid farnesylation 
OBSOLETE. The covalent or non-covalent attachment of a farnesyl group to the carboxy terminus of a protein. [GOC:jl]
National Institutes of Health

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Protein Prenylation

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2017
2017
Burn-induced muscle metabolic derangements and mitochondrial dysfunction are associated with activation of HIF-1α and mTORC1: Role of protein farnesylation
Metabolic derangements are a clinically significant complication of major trauma (e.g., burn injury) and include various aspects… 
2008
2008
SCH66336, inhibitor of protein farnesylation, blocks signal transducer and activators of transcription 3 signaling in lung cancer and interacts with a small molecule inhibitor of epidermal growth…
Signal transducer and activators of transcription 3 (STAT3) is an important transcription factor that is essential for lung… 
2006
2006
In vitro and in vivo analysis of the role of Pex19p farnesylation and Pex14p phosphorylation in peroxisome biogenesis
2005
2005
Tools to analyze protein farnesylation in cells.
Farnesylation of proteins is catalyzed by protein farnesyl transferase (FTase) and is obligatory for the function of the… 
2004
2004
Getting a handle on protein farnesylation
A new technique based on the Staudinger ligation has enabled researchers to conduct a broad analysis of cellular targets of… 
2003
2003
Phase I I a nd P harmacodynamic S tudy o f t he Farnesyltransfer ase I nhibitor R 115777 a s I nitial T herapy i n Patients W ith M etastatic P ancreatic A denocarcinoma
Purpose: R115777 is a selective nonpeptidomimetic inhibitor of farnesyltransferase (FTase), one of several enzymes responsible… 
1999
1999
Characterization of the Ras homologue of Schistosoma mansoni.
Highly Cited
1998
Highly Cited
1998
Lovastatin inhibits proliferation of pancreatic cancer cell lines with mutant as well as with wild-type K-ras oncogene but has different effects on protein phosphorylation and induction of apoptosis.
Besides its pharmacological effect on cholesterol biosynthesis, lovastatin inhibits p21ras proteins by substrate depletion for… 
1998
1998
Antiapoptotic signaling by the insulin receptor in Chinese hamster ovary cells.
We have sought to determine whether insulin can promote cell survival and protect Chinese hamster ovary (CHO) cells from… 
1997
1997
Geranylgeraniol potentiates lovastatin inhibition of oncogenic H-Ras processing and signaling while preventing cytotoxicity
Oncogenic H-Ras requires farnesylation for its transforming activity. Lovastatin inhibits both protein farnesylation and… 
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