Proinsulin, human

Known as: Insulin Precursor, Proinsulin 
Proinsulin (110 aa, ~12 kDa) is encoded by the human INS gene. This protein plays a role in the modulation of glucose metabolism.
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2011
Highly Cited
2011
OBJECTIVE Proinsulin is a precursor of mature insulin and C-peptide. Higher circulating proinsulin levels are associated with… (More)
  • figure 1
  • figure 4
  • figure 2
  • figure 3
Is this relevant?
Highly Cited
2008
Highly Cited
2008
Variation within six novel genetic loci has been reported to confer risk of type 2 diabetes and may be associated with beta cell… (More)
  • table 1
  • table 2
Is this relevant?
Highly Cited
2003
Highly Cited
2003
Accumulating evidence favors a role for proinsulin as a key autoantigen in diabetes. In the mouse, two proinsulin isoforms… (More)
  • table 1
  • figure 1
  • figure 2
  • figure 3
  • figure 4
Is this relevant?
Highly Cited
2003
Highly Cited
2003
Autosomal dominant diabetes in the Akita mouse is caused by mutation of the insulin 2 gene, whose product replaces a cysteine… (More)
  • figure 1
  • figure 2
  • figure 5
  • figure 4
  • figure 6
Is this relevant?
Highly Cited
2002
Highly Cited
2002
The neuroendocrine processing endoproteases PC2 and PC1/3 are expressed in the beta cells of the islets of Langerhans and… (More)
  • table 1
  • figure 1
  • figure 2
  • figure 4
  • figure 3
Is this relevant?
Highly Cited
1993
Highly Cited
1993
We describe an enzyme-linked two-site immunoassay for quantitation of intact insulin in human serum and plasma. The method uses… (More)
  • figure 1
  • table 2
  • table 1
Is this relevant?
Highly Cited
1993
Highly Cited
1993
Conventional immunoassays to quantify insulin concentration do not differentiate between insulin and proinsulin. Thus, previous… (More)
Is this relevant?
Highly Cited
1989
Highly Cited
1989
Monoclonal antibody-based two-site immunoradiometric assays are described for human insulin, proinsulin, 65-66 split and 32-33… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
Highly Cited
1987
Highly Cited
1987
In this study, we found that the ratio of proinsulin to total immunoreactive insulin was much higher in 22 patients with Type 2… (More)
  • table 1
  • table 2
Is this relevant?
Highly Cited
1975
Highly Cited
1975
Concentrations of insulin, proinsulin, and C-peptide were measured in portal and peripheral venous blood in six nondiabetic… (More)
  • table I
  • figure 1
  • figure 3
  • figure 2
  • table II
Is this relevant?