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Proinsulin, human

Known as: Insulin Precursor, Proinsulin 
Proinsulin (110 aa, ~12 kDa) is encoded by the human INS gene. This protein plays a role in the modulation of glucose metabolism.
National Institutes of Health

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9 relations
Assay of ProinsulinCarbohydrate MetabolismEnergy MetabolismINS gene

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
1999
Highly Cited
1999
Long-term elevation of free fatty acids leads to delayed processing of proinsulin and prohormone convertases 2 and 3 in the pancreatic beta-cell line MIN6.
To explore the role of chronically elevated free fatty acids (FFAs) in the pathogenesis of the hyperproinsulinemia of type 2… 
Highly Cited
1992
Highly Cited
1992
Preferential cleavage of des-31,32-proinsulin over intact proinsulin by the insulin secretory granule type II endopeptidase. Implication of a favored route for prohormone processing.
Highly Cited
1988
Highly Cited
1988
Evidence of IgG Autoantibodies Against Human Proinsulin in Patients With IDDM Before Insulin Treatment
IgG proinsulin autoantibodies (IgG-PAAs) have been found in a fraction of sera from patients with newly diagnosed insulin… 
Highly Cited
1978
Highly Cited
1978
The stimulus-secretion coupling of glucose-induced insulin release. Metabolic effects of menadione in isolated islets.
Pancreatic islets contain an enzyme system which catalyzes the donation of hydrogen from NAD(P)H to menadione (2-methyl-1,4… 
Highly Cited
1977
Highly Cited
1977
Insulin receptors in patients with insulinomas: changes in receptor affinity and concentration.
We have measured the specific binding of 125I-insulin to insulin receptors on circulating monocytes from 5 patients with… 
Highly Cited
1974
Highly Cited
1974
Radioimmunoassay of human proinsulin C-peptide using synthetic human connecting peptide.
Radioimmunoassay of human C-peptide was established using antiserum to synthetic human connecting peptide and synthetic… 
Highly Cited
1973
Highly Cited
1973
Biological activity of proinsulin and related polypeptides in the fat tissue.
Abstract A number of insulin-like and proinsulin-like polypeptides were employed in the study of the structure-activity… 
Highly Cited
1972
Highly Cited
1972
Effect of chronic sulfonylurea therapy on plasma insulin and proinsulin levels.
ABSTRACT The effect of the chronic administration of glyburide, a potent sulfonylurea, on plasma glucose, insulin and proinsulin… 
Highly Cited
1971
Highly Cited
1971
The structure of bovine proinsulin.
Highly Cited
1971
Highly Cited
1971
Isolation and characterization of proinsulin C-peptide from bovine pancreas.
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