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Proinsulin, human
Known as:
Insulin Precursor
, Proinsulin
Proinsulin (110 aa, ~12 kDa) is encoded by the human INS gene. This protein plays a role in the modulation of glucose metabolism.
National Institutes of Health
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9 relations
Assay of Proinsulin
Carbohydrate Metabolism
Energy Metabolism
INS gene
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Highly Cited
1999
Highly Cited
1999
Obesity, weight change, fasting insulin, proinsulin, C-peptide, and insulin-like growth factor-1 levels in women with and without breast cancer: the Rancho Bernardo Study.
H. Jernström
,
E. Barrett-Connor
Journal of Womens Health & Gender-Based Medicine
1999
Corpus ID: 2455907
Postmenopausal overweight women have an increased risk of breast cancer. The link between obesity and breast cancer could be…
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Review
1994
Review
1994
Insulin secretory granule biogenesis and the proinsulin-processing endopeptidases
Dr. J. C. Hutton
Diabetologia
1994
Corpus ID: 443271
SummaryThe insulin storage granule of the pancreatic beta cell is assembled within the trans Golgi network from around 50 or so…
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Highly Cited
1992
Highly Cited
1992
Preferential cleavage of des-31,32-proinsulin over intact proinsulin by the insulin secretory granule type II endopeptidase. Implication of a favored route for prohormone processing.
C. Rhodes
,
B. Lincoln
,
S. Shoelson
Journal of Biological Chemistry
1992
Corpus ID: 31927312
Highly Cited
1988
Highly Cited
1988
Evidence of IgG Autoantibodies Against Human Proinsulin in Patients With IDDM Before Insulin Treatment
B. Kuglin
,
F. Gries
,
H. Kolb
Diabetes
1988
Corpus ID: 20953532
IgG proinsulin autoantibodies (IgG-PAAs) have been found in a fraction of sera from patients with newly diagnosed insulin…
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Highly Cited
1978
Highly Cited
1978
The stimulus-secretion coupling of glucose-induced insulin release. Metabolic effects of menadione in isolated islets.
W. Malaisse
,
J. Hutton
,
S. Kawazu
,
A. Sener
European Journal of Biochemistry
1978
Corpus ID: 22731569
Pancreatic islets contain an enzyme system which catalyzes the donation of hydrogen from NAD(P)H to menadione (2-methyl-1,4…
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Highly Cited
1977
Highly Cited
1977
Insulin receptors in patients with insulinomas: changes in receptor affinity and concentration.
ROBERT S. Bar
,
Phillip Gorden
,
J. Roth
,
Carolyn Siebert
Journal of Clinical Endocrinology and Metabolism
1977
Corpus ID: 34627037
We have measured the specific binding of 125I-insulin to insulin receptors on circulating monocytes from 5 patients with…
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Highly Cited
1974
Highly Cited
1974
Radioimmunoassay of human proinsulin C-peptide using synthetic human connecting peptide.
T. Kaneko
,
H. Oka
,
M. Munemura
,
T. Oda
,
K. Yamashita
Endocrinologia Japonica
1974
Corpus ID: 20199144
Radioimmunoassay of human C-peptide was established using antiserum to synthetic human connecting peptide and synthetic…
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Highly Cited
1972
Highly Cited
1972
Effect of chronic sulfonylurea therapy on plasma insulin and proinsulin levels.
W. Duckworth
,
S. Solomon
,
A. Kitabchi
Journal of Clinical Endocrinology and Metabolism
1972
Corpus ID: 36586162
ABSTRACT The effect of the chronic administration of glyburide, a potent sulfonylurea, on plasma glucose, insulin and proinsulin…
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Highly Cited
1971
Highly Cited
1971
The structure of bovine proinsulin.
C. Nolan
,
E. Margoliash
,
J. Peterson
,
D. Steiner
Journal of Biological Chemistry
1971
Corpus ID: 8792601
Highly Cited
1971
Highly Cited
1971
Isolation and characterization of proinsulin C-peptide from bovine pancreas.
D. Steiner
,
S. Cho
,
P. Oyer
,
S. Terris
,
J. Peterson
,
A. Rubenstein
Journal of Biological Chemistry
1971
Corpus ID: 29359425
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