Procollagen-Proline Dioxygenase

Known as: Peptidyl Proline Hydroxylase, Prolyl 4-Hydroxylase, Procollagen, Protocollagen Proline 4-Hydroxylase 
A mixed-function oxygenase that catalyzes the hydroxylation of a prolyl-glycyl containing peptide, usually in PROTOCOLLAGEN, to a hydroxyprolylglycyl… (More)
National Institutes of Health

Related topics

Related topics

19 relations
In BloodP4HA1 geneP4HA2 geneP4HB gene
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Broader (1)

Mixed Function Oxygenases

Narrower (4)

P4HA1 protein, humanP4hb protein, mousePHD2 protein, ratproline, 2-oxoglutarate 3-dioxygenase

Papers overview

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Highly Cited
2011
Highly Cited
2011
Pyruvate Kinase M2 Is a PHD3-Stimulated Coactivator for Hypoxia-Inducible Factor 1
The pyruvate kinase isoforms PKM1 and PKM2 are alternatively spliced products of the PKM2 gene. PKM2, but not PKM1, alters… (More)
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Highly Cited
2011
Highly Cited
2011
The oncometabolite 2-hydroxyglutarate inhibits histone lysine demethylases.
Mutations in isocitrate dehydrogenases (IDHs) have a gain-of-function effect leading to R(-)-2-hydroxyglutarate (R-2HG… (More)
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Review
2010
Review
2010
Hypoxia-inducible factors and the response to hypoxic stress.
Oxygen (O(2)) is an essential nutrient that serves as a key substrate in cellular metabolism and bioenergetics. In a variety of… (More)
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Highly Cited
2009
Highly Cited
2009
Downregulation of miR-199a derepresses hypoxia-inducible factor-1alpha and Sirtuin 1 and recapitulates hypoxia preconditioning in cardiac myocytes.
MicroRNAs are posttranscriptional gene regulators that are differentially expressed during various diseases and have been… (More)
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Review
2007
Review
2007
Hypoxia-inducible factor 1 (HIF-1) pathway.
Hypoxia-inducible factor 1 (HIF-1) is a basic helix-loop-helix-PAS domain transcription factor that is expressed in all metazoan… (More)
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Review
2006
Review
2006
Hypoxia-inducible factor-1 (HIF-1).
Adaptation to low oxygen tension (hypoxia) in cells and tissues leads to the transcriptional induction of a series of genes that… (More)
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Highly Cited
2005
Highly Cited
2005
Succinate links TCA cycle dysfunction to oncogenesis by inhibiting HIF-alpha prolyl hydroxylase.
Several mitochondrial proteins are tumor suppressors. These include succinate dehydrogenase (SDH) and fumarate hydratase, both… (More)
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Review
2005
Review
2005
Chronic hypoxia and tubulointerstitial injury: a final common pathway to end-stage renal failure.
Recent studies emphasize the role of chronic hypoxia in the tubulointerstitium as a final common pathway to end-stage renal… (More)
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Highly Cited
2003
Highly Cited
2003
Chemokine receptor CXCR4 downregulated by von Hippel–Lindau tumour suppressor pVHL
Organ-specific metastasis is governed, in part, by interactions between chemokine receptors on cancer cells and matching… (More)
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Highly Cited
2001
Highly Cited
2001
Regulation of drought tolerance by gene manipulation of 9-cis-epoxycarotenoid dioxygenase, a key enzyme in abscisic acid biosynthesis in Arabidopsis.
Abscisic acid (ABA), a plant hormone, is involved in responses to environmental stresses such as drought and high salinity, and… (More)
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