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- Publications
- Influence
Insulin-like growth factors I and II. Peptide, messenger ribonucleic acid and gene structures, serum, and tissue concentrations.
- W. Daughaday, P. Rotwein
- Biology, Medicine
- Endocrine reviews
- 1 February 1989
There is currently widespread interest in the IGFs (IGF-I and IGF-II) and their roles in the regulation of growth and differentiation of an ever increasing number of tissues are being reported. This… Expand
Inhibition of access of bound somatomedin to membrane receptor and immunobinding sites: a comparison of radioreceptor and radioimmunoassay of somatomedin in native and acid-ethanol-extracted serum.
- W. Daughaday, I. Mariz, S. Blethen
- Chemistry, Medicine
- The Journal of clinical endocrinology and…
- 1 October 1980
No agreement exists concerning the necessity for extracting serum somatomedin (Sm) before radioreceptor assay (RRA) and RIA. We have developed a simplified system of Sm extraction which has permitted… Expand
Synthesis and secretion of insulin-like growth factor II by a leiomyosarcoma with associated hypoglycemia.
- W. Daughaday, M. Emanuele, M. Brooks, A. L. Barbato, M. Kapadia, P. Rotwein
- Medicine
- The New England journal of medicine
- 1 December 1988
We describe a case of recurrent hypoglycemia apparently caused by secretion of insulin-like growth factor II (IGF-II) by a leiomyosarcoma. A 67-year-old woman presented with recurrent severe… Expand
A hormonally controlled serum factor which stimulates sulfate incorporation by cartilage in vitro.
- W. D. Salmon, W. Daughaday
- Biology, Medicine
- The Journal of laboratory and clinical medicine
- 1 June 1957
Impaired formation of the ternary insulin-like growth factor-binding protein complex in patients with hypoglycemia due to nonislet cell tumors.
- R. Baxter, W. Daughaday
- Biology, Medicine
- The Journal of clinical endocrinology and…
- 1 October 1991
In some subjects with hypoglycemia associated with tumors of mesenchymal origin, high insulin-like growth factor-II (IGF-II) levels have been described in serum and in the tumors. Tumor IGF-II of… Expand
Insulin-like growth factor II acts as an autocrine growth and motility factor in human rhabdomyosarcoma tumors.
- O. el-Badry, C. Minniti, E. Kohn, P. Houghton, W. Daughaday, L. Helman
- Biology, Medicine
- Cell growth & differentiation : the molecular…
- 1 July 1990
Rhabdomyosarcoma is the most common soft tissue sarcoma of childhood and appears to arise from developing striated muscle-forming cells. Since insulin-like growth factor II (IGF-II) is involved in… Expand
Serum "big insulin-like growth factor II" from patients with tumor hypoglycemia lacks normal E-domain O-linked glycosylation, a possible determinant of normal propeptide processing.
- W. Daughaday, B. Trivedi, R. Baxter
- Biology, Medicine
- Proceedings of the National Academy of Sciences…
- 15 June 1993
The insulin-like growth factor II (IGF-II) gene is overexpressed in many mesenchymal tumors and can lead to non-islet-cell tumor hypoglycemia (NICTH). ProIGF-II consists of the 67 aa of IGF-II with a… Expand
Somatomedin: Proposed Designation for Sulphation Factor
- W. Daughaday, K. Hall, M. S. Raben, W. D. J. Salmon, J. Brande, J. J. V. Wyk
- Chemistry, Medicine
- Nature
- 14 January 1972
THE action of growth hormone (GH) on skeletal tissue was proposed to be mediated through a secondary substance, described by the operational term “sulphation factor”1. The observations underlying… Expand
The possible autocrine/paracrine and endocrine roles of insulin-like growth factors of human tumors.
- W. Daughaday
- Biology, Medicine
- Endocrinology
- 1 July 1990
Imbalanced expression of the glucocorticoid receptor isoforms in cultured lymphocytes from a patient with systemic glucocorticoid resistance and chronic lymphocytic leukemia.
- H. Shahidi, A. Vottero, +7 authors J. Plate
- Biology, Medicine
- Biochemical and biophysical research…
- 27 January 1999
The human glucocorticoid receptor (GR) is expressed as two alternatively spliced isoforms, GRalpha and GRbeta. Whereas GRalpha is a hormone-activated transcription factor, GRbeta does not bind… Expand