• Publications
  • Influence
Impaired insulin and insulin-like growth factor expression and signaling mechanisms in Alzheimer's disease--is this type 3 diabetes?
The neurodegeneration that occurs in sporadic Alzheimer's disease (AD) is consistently associated with a number of characteristic histopathological, molecular, and biochemical abnormalities,Expand
  • 1,215
  • 66
  • PDF
Insulin and insulin-like growth factor expression and function deteriorate with progression of Alzheimer's disease: link to brain reductions in acetylcholine.
Reduced glucose utilization and energy metabolism occur early in the course of Alzheimer's disease (AD) and correlate with impaired cognition. Glucose utilization and energy metabolism are regulatedExpand
  • 532
  • 33
Selective G to T mutations of p53 gene in hepatocellular carcinoma from southern Africa
HEPATOCELLULAR carcinoma (HCC) is a prevalent cancer in sub-Saharan Africa and eastern Asia1. Hepatitis B virus and aflatoxins are risk factors for HCC2, but the molecular mechanism of humanExpand
  • 1,382
  • 29
Alzheimer's Disease is Type 3 Diabetes—Evidence Reviewed
Alzheimer's disease (AD) has characteristic histopathological, molecular, and biochemical abnormalities, including cell loss; abundant neurofibrillary tangles; dystrophic neurites; amyloid precursorExpand
  • 680
  • 27
  • PDF
Intracerebral streptozotocin model of type 3 diabetes: relevance to sporadic Alzheimer's disease.
The cascade of Alzheimer's disease (AD) neurodegeneration is associated with persistent oxidative stress, mitochondrial dysfunction, impaired energy metabolism, and activation of pro-death signalingExpand
  • 392
  • 26
Randomized controlled trial testing the effects of weight loss on nonalcoholic steatohepatitis
Nonalcoholic steatohepatitis (NASH) is a chronic progressive liver disease that is strongly associated with obesity. Currently, there is no approved therapy for NASH. Weight reduction is typicallyExpand
  • 838
  • 25
Cloning and Characterization of a Novel Hepatitis B Virus x Binding Protein That Inhibits Viral Replication
ABSTRACT The hepatitis B virus and the mammalian hepadnavirus genomes encode for a short open reading frame called x. Expression of the protein product (HBx) appears necessary for establishment ofExpand
  • 206
  • 20
  • PDF
Therapeutic rescue of neurodegeneration in experimental type 3 diabetes: relevance to Alzheimer's disease.
Alzheimer's disease (AD) is associated with major impairments in insulin and insulin-like growth factor (IGF) gene expression and signaling in the brain. These abnormalities increase with severity ofExpand
  • 286
  • 20
Abnormal structure and expression of p53 gene in human hepatocellular carcinoma.
There is little information regarding the molecular mechanisms of hepatocarcinogenesis. We studied the p53 gene at the DNA, RNA, and protein level in seven human hepatocellular carcinomaExpand
  • 367
  • 15
Review of insulin and insulin-like growth factor expression, signaling, and malfunction in the central nervous system: relevance to Alzheimer's disease.
Interest in characterizing the role of impaired insulin actions in Alzheimer's disease (AD) and vascular dementia is growing exponentially. This review details what is currently known about insulin,Expand
  • 469
  • 13
  • PDF