Prions

Known as: prion proteins, prion protein, Prions [Chemical/Ingredient] 
Small proteinaceous infectious particles which resist inactivation by procedures that modify NUCLEIC ACIDS and contain an abnormal isoform of a… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1939-2018
010020019392017

Papers overview

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Review
2016
Review
2016
Frontotemporal dementia is a devastating neurodegenerative disease causing stark alterations in personality and language… (More)
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Highly Cited
2009
Highly Cited
2009
In variant Creutzfeldt–Jakob disease, prions (PrPSc) enter the body with contaminated foodstuffs and can spread from the… (More)
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Highly Cited
2007
Highly Cited
2007
The conformational change of a host protein, PrP(C), into a disease-associated isoform, PrP(Sc), appears to play a critical role… (More)
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Highly Cited
2005
Highly Cited
2005
Prions are unconventional infectious agents responsible for transmissible spongiform encephalopathy (TSE) diseases. They are… (More)
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Highly Cited
2004
Highly Cited
2004
Recombinant mouse prion protein (recMoPrP) produced in Escherichia coli was polymerized into amyloid fibrils that represent a… (More)
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Highly Cited
2004
Highly Cited
2004
Prion diseases are infectious neurodegenerative disorders linked to the accumulation in the central nervous system of the… (More)
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Highly Cited
2001
Highly Cited
2001
Prions are self-propagating protein conformations. Recent research brought insight into prion propagation, but how they first… (More)
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Highly Cited
1996
Highly Cited
1996
The 'protein only' hypothesis postulates that the prion, the agent causing transmissible spongiform encephalopathies, is PrP(Sc… (More)
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Highly Cited
1993
Highly Cited
1993
Prions are composed largely, if not entirely, of prion protein (PrPSc in the case of scrapie). Although the formation of PrPSc… (More)
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Highly Cited
1983
Highly Cited
1983
A large scale purification protocol employing zonal rotor centrifugation has been developed for scrapie prions. The extensively… (More)
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