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Prions

Known as: prion proteins, prion protein, Prions [Chemical/Ingredient] 
Small proteinaceous infectious particles which resist inactivation by procedures that modify NUCLEIC ACIDS and contain an abnormal isoform of a… 
National Institutes of Health

Related topics

Related topics

22 relations
In BloodPRND genePRNP genePRNT gene

Narrower (7)

PRND protein, humanPrP 27-30 ProteinPrion ProteinsPrnd protein, mouse

Broader (1)

Viroids

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2015
Highly Cited
2015
A naturally occurring variant of the human prion protein completely prevents prion disease
Mammalian prions, transmissible agents causing lethal neurodegenerative diseases, are composed of assemblies of misfolded… 
Highly Cited
2014
Highly Cited
2014
Parallel In-register Intermolecular β-Sheet Architectures for Prion-seeded Prion Protein (PrP) Amyloids*
Background: The structures of infectious mammalian prions remain unclear. Results: Based in part on NMR data, we developed models… 
Highly Cited
2005
Highly Cited
2005
PrPSc in mammary glands of sheep affected by scrapie and mastitis
Highly Cited
2001
Highly Cited
2001
The elimination of the yeast [PSI+] prion by guanidine hydrochloride is the result of Hsp104 inactivation
In the yeast Saccharomyces cerevisiae, Sup35p (eRF3), a subunit of the translation termination complex, can take up a prion‐like… 
Highly Cited
2000
Highly Cited
2000
Species-barrier-independent prion replication in apparently resistant species.
Transmission of prions between mammalian species is thought to be limited by a "species barrier," which depends on differences in… 
Highly Cited
2000
Highly Cited
2000
[URE3] Prion Propagation in Saccharomyces cerevisiae: Requirement for Chaperone Hsp104 and Curing by Overexpressed Chaperone Ydj1p
ABSTRACT The [URE3] nonchromosomal genetic element is an infectious form (prion) of the Ure2 protein, apparently a self… 
Highly Cited
1999
Highly Cited
1999
Scrapie replication in lymphoid tissues depends on prion protein-expressing follicular dendritic cells
The immune system is central in the pathogenesis of scrapie and other transmissible spongiform encephalopathies (TSEs) or 'prion… 
Highly Cited
1993
Highly Cited
1993
Conformational transitions, dissociation, and unfolding of scrapie amyloid (prion) protein.
The infectious form of the scrapie amyloid (prion) precursor, PrPSc, is a host-derived protein and a component of the infectious… 
Highly Cited
1992
Highly Cited
1992
Predicted alpha-helical regions of the prion protein when synthesized as peptides form amyloid.
By comparing the amino acid sequences of 11 mammalian and 1 avian prion proteins (PrP), structural analyses predicted four alpha… 
Highly Cited
1992
Highly Cited
1992
Glycosylinositol phospholipid anchors of the scrapie and cellular prion proteins contain sialic acid.
The only identified component of the scrapie prion is PrPSc, a glycosylinositol phospholipid (GPI)-linked protein that is derived… 
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