Prion Proteins

Known as: Fatal Familial Insomnia Protein, Major Prion Protein, PrP Proteins 
Membrane glycosylphosphatidylinositol-anchored glycoproteins that may aggregate into rod-like structures. The prion protein (PRNP) gene is… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1986-2018
0204019862018

Papers overview

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Highly Cited
2013
Highly Cited
2013
During prion disease, an increase in misfolded prion protein (PrP) generated by prion replication leads to sustained… (More)
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Highly Cited
2012
Highly Cited
2012
The mechanisms leading to neuronal death in neurodegenerative disease are poorly understood. Many of these disorders, including… (More)
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Highly Cited
2010
Highly Cited
2010
The prion hypothesis posits that a misfolded form of prion protein (PrP) is responsible for the infectivity of prion disease… (More)
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Highly Cited
2005
Highly Cited
2005
In prion and Alzheimer's diseases, the roles played by amyloid versus nonamyloid deposits in brain damage remain unresolved. In… (More)
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Highly Cited
2002
Highly Cited
2002
Prion protein (PrP) plays a crucial role in prion disease, but its physiological function remains unclear. Mice with gene… (More)
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Highly Cited
2001
Highly Cited
2001
Recently, we identified the 37-kDa laminin receptor precursor (LRP) as an interactor for the prion protein (PrP). Here, we show… (More)
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Highly Cited
1999
Highly Cited
1999
There is growing concern that bovine spongiform encephalopathy (BSE) may have passed from cattle to humans. We report here that… (More)
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Highly Cited
1998
Highly Cited
1998
At the endoplasmic reticulum membrane, the prion protein (PrP) can be synthesized in several topological forms. The role of these… (More)
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Highly Cited
1996
Highly Cited
1996
THERE is a wealth of data supporting a central role for the prion protein (PrP) in the neurodegenerative prion diseases of both… (More)
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Highly Cited
1992
Highly Cited
1992
BACKGROUND We previously described two members of a family affected by an apparently genetically determined fatal disease… (More)
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