Skip to search form
Skip to main content
Skip to account menu
Semantic Scholar
Semantic Scholar's Logo
Search 217,275,345 papers from all fields of science
Search
Sign In
Create Free Account
Prion Proteins
Known as:
Fatal Familial Insomnia Protein
, Major Prion Protein
, PrP Proteins
Expand
Membrane glycosylphosphatidylinositol-anchored glycoproteins that may aggregate into rod-like structures. The prion protein (PRNP) gene is…
Expand
National Institutes of Health
Create Alert
Alert
Related topics
Related topics
14 relations
Alternative Prion Protein
In Blood
PRNP gene
Process of secretion
Expand
Narrower (3)
Major Prion Protein
Prnp protein, leucyl(101), mouse
Prnp protein, mouse
Broader (1)
Prions
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2013
Highly Cited
2013
Oral Treatment Targeting the Unfolded Protein Response Prevents Neurodegeneration and Clinical Disease in Prion-Infected Mice
J. Moreno
,
M. Halliday
,
+8 authors
G. Mallucci
Science Translational Medicine
2013
Corpus ID: 25570626
Pharmacological inhibition of PERK, the key kinase of the unfolded protein response that mediates translational shutdown…
Expand
Highly Cited
2010
Highly Cited
2010
Generating a Prion with Bacterially Expressed Recombinant Prion Protein
Fei Wang
,
Xinhe Wang
,
C. Yuan
,
Jiyan Ma
Science
2010
Corpus ID: 52859827
Recombinant Infectious Prions Prion diseases are a group of fatal neurodegenerative disorders that include Creutzfeldt-Jakob…
Expand
Highly Cited
2010
Highly Cited
2010
Synthetic amyloid-β oligomers impair long-term memory independently of cellular prion protein
C. Balducci
,
M. Beeg
,
+11 authors
G. Forloni
Proceedings of the National Academy of Sciences…
2010
Corpus ID: 22223792
Inability to form new memories is an early clinical sign of Alzheimer’s disease (AD). There is ample evidence that the amyloid…
Expand
Highly Cited
2010
Highly Cited
2010
Memory Impairment in Transgenic Alzheimer Mice Requires Cellular Prion Protein
D. Gimbel
,
H. Nygaard
,
+4 authors
S. Strittmatter
Journal of Neuroscience
2010
Corpus ID: 16480359
Soluble oligomers of the amyloid-β (Aβ) peptide are thought to play a key role in the pathophysiology of Alzheimer's disease (AD…
Expand
Highly Cited
2005
Highly Cited
2005
Anchorless Prion Protein Results in Infectious Amyloid Disease Without Clinical Scrapie
B. Chesebro
,
M. Trifilo
,
+10 authors
M. Oldstone
Science
2005
Corpus ID: 10064966
In prion and Alzheimer's diseases, the roles played by amyloid versus nonamyloid deposits in brain damage remain unresolved. In…
Expand
Highly Cited
2002
Highly Cited
2002
Post‐natal knockout of prion protein alters hippocampal CA1 properties, but does not result in neurodegeneration
G. Mallucci
,
S. Ratté
,
+4 authors
J. Collinge
EMBO Journal
2002
Corpus ID: 29308062
Prion protein (PrP) plays a crucial role in prion disease, but its physiological function remains unclear Mice with gene…
Expand
Highly Cited
2001
Highly Cited
2001
Scrapie prion protein accumulation by scrapie-infected neuroblastoma cells abrogated by exposure to a prion protein antibody
M. Enari
,
E. Flechsig
,
Charles Weissmann
Proceedings of the National Academy of Sciences…
2001
Corpus ID: 20289491
Exposure of susceptible neuroblastoma N2a cells to mouse scrapie prions leads to infection, as evidenced by the continued…
Expand
Highly Cited
1999
Highly Cited
1999
Compelling transgenetic evidence for transmission of bovine spongiform encephalopathy prions to humans.
M. Scott
,
R. Will
,
+4 authors
S. Prusiner
Proceedings of the National Academy of Sciences…
1999
Corpus ID: 26017463
There is growing concern that bovine spongiform encephalopathy (BSE) may have passed from cattle to humans. We report here that…
Expand
Highly Cited
1996
Highly Cited
1996
Altered circadian activity rhythms and sleep in mice devoid of prion protein
I. Tobler
,
S. Gaus
,
+7 authors
J. Manson
Nature
1996
Corpus ID: 4256140
THERE is a wealth of data supporting a central role for the prion protein (PrP) in the neurodegenerative prion diseases of both…
Expand
Highly Cited
1992
Highly Cited
1992
Fatal familial insomnia, a prion disease with a mutation at codon 178 of the prion protein gene.
R. Medori
,
H. Tritschler
,
+17 authors
P. Gambetti
New England Journal of Medicine
1992
Corpus ID: 43553132
BACKGROUND We previously described two members of a family affected by an apparently genetically determined fatal disease…
Expand
By clicking accept or continuing to use the site, you agree to the terms outlined in our
Privacy Policy
(opens in a new tab)
,
Terms of Service
(opens in a new tab)
, and
Dataset License
(opens in a new tab)
ACCEPT & CONTINUE