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Prion Proteins

Known as: Fatal Familial Insomnia Protein, Major Prion Protein, PrP Proteins 
Membrane glycosylphosphatidylinositol-anchored glycoproteins that may aggregate into rod-like structures. The prion protein (PRNP) gene is… 
National Institutes of Health

Papers overview

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Highly Cited
2013
Highly Cited
2013
Pharmacological inhibition of PERK, the key kinase of the unfolded protein response that mediates translational shutdown… 
Highly Cited
2010
Highly Cited
2010
Recombinant Infectious Prions Prion diseases are a group of fatal neurodegenerative disorders that include Creutzfeldt-Jakob… 
Highly Cited
2010
Highly Cited
2010
Inability to form new memories is an early clinical sign of Alzheimer’s disease (AD). There is ample evidence that the amyloid… 
Highly Cited
2010
Highly Cited
2010
Soluble oligomers of the amyloid-β (Aβ) peptide are thought to play a key role in the pathophysiology of Alzheimer's disease (AD… 
Highly Cited
2005
Highly Cited
2005
In prion and Alzheimer's diseases, the roles played by amyloid versus nonamyloid deposits in brain damage remain unresolved. In… 
Highly Cited
2002
Highly Cited
2002
Prion protein (PrP) plays a crucial role in prion disease, but its physiological function remains unclear Mice with gene… 
Highly Cited
2001
Highly Cited
2001
Exposure of susceptible neuroblastoma N2a cells to mouse scrapie prions leads to infection, as evidenced by the continued… 
Highly Cited
1999
Highly Cited
1999
There is growing concern that bovine spongiform encephalopathy (BSE) may have passed from cattle to humans. We report here that… 
Highly Cited
1996
Highly Cited
1996
THERE is a wealth of data supporting a central role for the prion protein (PrP) in the neurodegenerative prion diseases of both… 
Highly Cited
1992
Highly Cited
1992
BACKGROUND We previously described two members of a family affected by an apparently genetically determined fatal disease…