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Presenilin-2

Known as: AD3LP, EC 3.4.23.-, Presenilin-2 [Chemical/Ingredient] 
Integral membrane protein of Golgi and endoplasmic reticulum. Its homodimer is an essential component of the gamma-secretase complex that catalyzes… Expand
National Institutes of Health

Papers overview

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Review
2018
Review
2018
Alzheimer disease (AD) is a debilitating dementia believed to result from the deposition of extracellular amyloid-β (A… Expand
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Highly Cited
2000
Highly Cited
2000
Nicastrin, a transmembrane glycoprotein, forms high molecular weight complexes with presenilin 1 and presenilin 2. Suppression of… Expand
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Highly Cited
2000
Highly Cited
2000
he question of how proteins such as the β-amyloid precursor protein (β-APP), Notch-1 and others can be cleaved in the plane of… Expand
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Highly Cited
2000
Highly Cited
2000
Presenilins are required for γ -secretase cleavage of β -APP and transmembrane cleavage of Notch-1 
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Highly Cited
2000
Highly Cited
2000
Mutations in the highly homologous presenilin genes encoding presenilin-1 and presenilin-2 (PS1 and PS2) are linked to early… Expand
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Highly Cited
1998
Highly Cited
1998
Most early-onset familial Alzheimer disease (AD) cases are caused by mutations in the highly related genes presenilin 1 (PS1) and… Expand
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Highly Cited
1997
Highly Cited
1997
Approximately 10% of cases of Alzheimer's disease are familial and associated with autosomal dominant inheritance of mutations in… Expand
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Highly Cited
1996
Highly Cited
1996
To determine whether the presenilin 1 (PS1), presenilin 2 (PS2) and amyloid β-protein precursor (APP) mutations linked to… Expand
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Highly Cited
1996
Highly Cited
1996
Overexpression of the familial Alzheimer's disease gene Presenilin 2 (PS2) in nerve growth factor-differentiated PC12 cells… Expand
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Highly Cited
1995
Highly Cited
1995
WE report the cloning of a novel gene (E5-1) encoded on chromosome 1 which has substantial nucleotide and amino-acid sequence… Expand
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