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Presenilin-2

Known as: AD3LP, EC 3.4.23.-, Presenilin-2 [Chemical/Ingredient] 
Integral membrane protein of Golgi and endoplasmic reticulum. Its homodimer is an essential component of the gamma-secretase complex that catalyzes… 
National Institutes of Health

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Related topics

27 relations
Alzheimer's DiseaseAlzheimer's Disease Pathway KEGGAspartic Acid ProteasesEnzyme Gene

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PSEN2 protein, human

Papers overview

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2008
2008
Cetuximab retargeting of adenovirus via the epidermal growth factor receptor for treatment of intraperitoneal ovarian cancer.
Gene and virotherapy of ovarian cancer, using type 5 adenovirus (Ad5), has demonstrated good activity in preclinical animal… 
Review
2005
Review
2005
Expression and activity of β-site amyloid precursor protein cleaving enzyme in Alzheimer's disease
Several lines of evidence indicate that the Aβ peptide is involved at some level in the pathological process that results in the… 
2005
2005
Adenovirus-directed ocular innate immunity: the role of conjunctival defensin-like chemokines (IP-10, I-TAC) and phagocytic human defensin-alpha.
PURPOSE Adenovirus (Ad), a major cause of viral conjunctivitis worldwide, is controlled initially by the innate immune response… 
2000
2000
Oligomerization properties of the viral oncoproteins adenovirus E1A and human papillomavirus E7 and their complexes with the retinoblastoma protein.
Human papillomavirus 16 E7 (HPV16 E7) and adenovirus 5 E1A (Ad5 E1A) are encoded by highly divergent viruses yet are functionally… 
Highly Cited
1999
Highly Cited
1999
Characterization of Detergent‐Insoluble Complexes Containing the Familial Alzheimer’s Disease‐Associated Presenilins
Abstract: Many cases of early‐onset familial Alzheimer’s disease have been linked to mutations within two genes encoding the… 
Highly Cited
1998
Highly Cited
1998
Structural Determinants Present in the C-terminal Binding Protein Binding Site of Adenovirus Early Region 1A Proteins*
The C-terminal binding protein (CtBP) has previously been shown to bind to a highly conserved six-amino acid motif very close to… 
Highly Cited
1990
Highly Cited
1990
Relative accessibility of N-acetylglucosamine in trimers of the adenovirus types 2 and 5 fiber proteins
Fiber is an adenovirus capsid protein responsible for virus attachment to the cell surface and contains O-linked N… 
Highly Cited
1989
Highly Cited
1989
Mouse anti-adenovirus cytotoxic T lymphocytes. Inhibition of lysis by E3 gp19K but not E3 14.7K.
Early region E3 of adenovirus (Ad) appears to encode proteins involved in the interaction of the virus with the host immune… 
Highly Cited
1985
Highly Cited
1985
Tumorigenicity of adenovirus-transformed cells: region E1A of adenovirus 12 confers resistance to natural killer cells.
Highly Cited
1979
Highly Cited
1979
Physical mapping of a large-plaque mutation of adenovirus type 2
We have developed a simple method based on cotransfection of overlapping DNA restriction fragments for construction of… 
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