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Regulation of Histone Acetylation in the Nucleus by Sphingosine-1-Phosphate
Epigenetic Signals The lipid sphingosine-1-phosphate (S1P) is a signaling molecule that binds to receptors on the cell surface to initiate biochemical changes that control a range of biological… Expand
p53 Sites Acetylated In Vitro by PCAF and p300 Are Acetylated In Vivo in Response to DNA Damage
- L. Liu, D. M. Scolnick, +4 authors S. Berger
- Biology, Medicine
- Molecular and Cellular Biology
- 1 February 1999
ABSTRACT The p53 tumor suppressor protein is a sequence-specific transcription factor that modulates the response of cells to DNA damage. Recent studies suggest that full transcriptional activity of… Expand
Acetylation of the p53 DNA-binding domain regulates apoptosis induction.
The ability of p53 to induce apoptosis plays an important role in tumor suppression. Here, we describe a previously unknown posttranslational modification of the DNA-binding domain of p53. This… Expand
Virtual ligand screening of the p300/CBP histone acetyltransferase: identification of a selective small molecule inhibitor.
The histone acetyltransferase (HAT) p300/CBP is a transcriptional coactivator implicated in many gene regulatory pathways and protein acetylation events. Although p300 inhibitors have been reported,… Expand
DNA recognition by GAL4: structure of a protein-DNA complex
A specific DNA complex of the 65-residue, N-terminal fragment of the yeast transcriptional activator, GAL4, has been analysed at 2.7 Å resolution by X-ray crystallography. The protein binds as a… Expand
Inhibition of Eukaryotic DNA Replication by Geminin Binding to Cdt1
Phosphorylation of serine 10 in histone H3 is functionally linked in vitro and in vivo to Gcn5-mediated acetylation at lysine 14.
Multiple covalent modifications exist in the amino-terminal tails of core histones, but whether a relationship exists between them is unknown. We examined the relationship between serine 10… Expand
Maintenance of low histone ubiquitylation by Ubp10 correlates with telomere-proximal Sir2 association and gene silencing.
Low levels of histone covalent modifications are associated with gene silencing at telomeres and other regions in the yeast S. cerevisiae. Although the histone deacetylase Sir2 maintains low… Expand
The structural basis of protein acetylation by the p300/CBP transcriptional coactivator
The transcriptional coactivator p300/CBP (CREBBP) is a histone acetyltransferase (HAT) that regulates gene expression by acetylating histones and other transcription factors. Dysregulation of… Expand
Structure of a human ASF1a–HIRA complex and insights into specificity of histone chaperone complex assembly
- Yong Tang, Maxim V Poustovoitov, +5 authors R. Marmorstein
- Biology, Medicine
- Nature Structural &Molecular Biology
Human HIRA, ASF1a, ASF1b and CAF-1 are evolutionally conserved histone chaperones that form multiple functionally distinct chromatin-assembly complexes, with roles linked to diverse nuclear process,… Expand