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Potassium Channel Openers [MoA]

Known as: Potassium Channel Activators, Potassium Channel Openers 
National Institutes of Health

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Potassium Channel Opener [EPC]ezogabine

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2008
2008
Synthesis and activity on rat aorta rings and rat pancreatic beta-cells of ring-opened analogues of benzopyran-type potassium channel activators.
2002
2002
The novel diazoxide analog 3-isopropylamino-7-methoxy-4H-1,2,4-benzothiadiazine 1,1-dioxide is a selective Kir6.2/SUR1 channel opener.
ATP-sensitive K(+) (K(ATP)) channels are activated by a diverse group of compounds known as potassium channel openers (PCOs… 
2002
2002
6-Sulfonylchromenes as highly potent K(ATP)-channel openers.
We synthesized K(ATP)-channel openers (KCOs) composed of the 4-pyridonechromene moiety of bimakalim (1) and a variety of sulfonyl… 
1999
1999
Potassium channel openers antagonize the effects of class III antiarrhythmic agents in canine Purkinje fiber action potentials. Implications for prevention of proarrhythmia induced by class III…
We studied the effects of potassium channel openers (PCOs) on frequency dependent prolongations of action potential duration (APD… 
1997
1997
Potassium channel opener-augmented cardioplegia: protection of myocyte contractility with chronic left ventricular dysfunction.
BACKGROUND An increased number of patients with preexisting left ventricular (LV) dysfunction and congestive heart failure (CHF… 
1997
1997
Hyperpolarized cardioplegic arrest with nicorandil: advantages over other potassium channel openers.
BACKGROUND Our laboratory has demonstrated that the potassium channel openers (PCOs) aprikalim and pinacidil are effective… 
1996
1996
N-aryl-3,3,3-trifluoro-2-hydroxy-2-methylpropanamides: KATP potassium channel openers. Modifications on the western region.
A subset of antiandrogen compounds, the N-aryl-3,3,3-trifluoro-2-hydroxy-2-methylpropanamides 1, were found to activate ATP… 
Review
1995
Review
1995
Ischemic myocardial cell protection conferred by the opening of ATP-sensitive potassium channels
SummaryThe responses of the cardiac myocyte to a potentially injurious ischemic stress are multiple. The opening of the ATP… 
1990
1990
K(+)-channel openers for relaxation of isolated penile erectile tissue from rabbit.
1990
1990
Effects of pinacidil on isolated human corpus cavernosum penis.
Intracavernous injection of vasoactive agents causing vasodilatation is widely recognized in the diagnosis and treatment of… 
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