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New developments on thromboxane and prostacyclin modulators part I: thromboxane modulators.
TLDR
This review will propose a description of the recently described thromboxane modulators of major interest, which combine another pharmacological activity such as, platelet activating factor antagonism, angiotensin II antagonism or 5-lipoxygenase inhibition. Expand
Study of the influence of both cyclodextrins and L-lysine on the aqueous solubility of nimesulide; isolation and characterization of nimesulide-L-lysine-cyclodextrin complexes.
TLDR
The purpose of the present study was to investigate the interaction of both cyclodextrins and L-lysine on the aqueous solubility of nimesulide. Expand
Inhibitory effect of curcuminoids and tetrahydrocurcuminoids on equine activated neutrophils and myeloperoxidase activity.
TLDR
Curcuminoids and THC had dose-dependent inhibitory effects on ROS production and MPO release by activated neutrophils and on purified MPO activity that open therapeutic perspectives in equine pathologies with excessive inflammatory reactions. Expand
Pharmacological evaluation of the novel thromboxane modulator BM-567 (II/II). Effects of BM-567 on osteogenic sarcoma-cell-induced platelet aggregation.
TLDR
Results obtained showed that this drug inhibited both MG-63 tumor-cell-induced platelet aggregation and platelet TXA(2) release following the tumor cell stimulation with IC(50) values of 3.04x10(-7) and 2.51x10 (-8)M, respectively. Expand
Identification and pharmacological characterization of succinate receptor agonists
TLDR
The succinate receptor (formerly GPR91 or SUCNR1) is described as a metabolic sensor that may be involved in homeostasis and the discovery of the first family of potent synthetic agonists is reported. Expand
New trends in dual 5-LOX/COX inhibition.
TLDR
Both COX and LOX derivatives (prostanoids and leukotrienes, respectively) are involved in other diseases than inflammation such as cancer proliferation where the use of dual inhibitors could be an interesting approach. Expand
Therapeutic and chemical developments of cholecystokinin receptor ligands
TLDR
The main biological role of CCK, the therapeutic potential ofCCK-A and CCK-B receptor agonists and antagonists and the common compounds from the different families of ligands are reviewed. Expand
Insight into SUCNR1 (GPR91) structure and function.
TLDR
SUCNR1 shows a high potential as an innovative drug target and is probably an important regulator of basic physiology and more specific pharmacological tools such as small-molecules modulators will represent an important asset in order to achieve the full characterization of this receptor. Expand
Recent development in the field of dual COX / 5-LOX inhibitors.
TLDR
Dual inhibitors, by acting on the two major arachidonic acid metabolic pathways, possess a wide range of anti-inflammatory activities and appear to be almost exempt from gastric toxicity, which is the most troublesome side effect of non-selective COX inhibitors. Expand
Evaluation of Original Dual Thromboxane A2 Modulators as Antiangiogenic Agents
TLDR
Data suggest that the original dual TXA2 inhibitors bear antiangiogenic properties, mainly by inhibiting endothelial cell migration. Expand
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