Positive Selection

The separation of specific cells or cell populations from a heterogeneous mixture. Specifically it refers to the selective retention of a population… (More)
National Institutes of Health

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Highly Cited
2008
Highly Cited
2008
Genome-wide scans for positively selected genes (PSGs) in mammals have provided insight into the dynamics of genome evolution… (More)
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Highly Cited
2007
Highly Cited
2007
With the advent of dense maps of human genetic variation, it is now possible to detect positive natural selection across the… (More)
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Highly Cited
2006
Highly Cited
2006
The identification of signals of very recent positive selection provides information about the adaptation of modern humans to… (More)
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Highly Cited
2005
Highly Cited
2005
Codon-based substitution models have been widely used to identify amino acid sites under positive selection in comparative… (More)
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Highly Cited
2005
Highly Cited
2005
Detecting positive Darwinian selection at the DNA sequence level has been a subject of considerable interest. However, positive… (More)
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Highly Cited
2003
Highly Cited
2003
Maximum-likelihood methods based on models of codon substitution accounting for heterogeneous selective pressures across sites… (More)
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Highly Cited
2002
Highly Cited
2002
The ability to detect recent natural selection in the human population would have profound implications for the study of human… (More)
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Highly Cited
1998
Highly Cited
1998
An excess of nonsynonymous substitutions over synonymous ones is an important indicator of positive selection at the molecular… (More)
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Highly Cited
1994
Highly Cited
1994
We have used organ culture of fetal thymic lobes from T cell receptor (TCR) transgenic beta 2M(-/-) mice to study the role of… (More)
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Highly Cited
1984
Highly Cited
1984
Mutations at the URA3 locus of Saccharomyces cerevisiae can be obtained by a positive selection. Wild-type strains of yeast (or… (More)
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