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Positive Selection

The separation of specific cells or cell populations from a heterogeneous mixture. Specifically it refers to the selective retention of a population… 
National Institutes of Health

Papers overview

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Highly Cited
2010
Highly Cited
2010
Extreme Evolutionary Disparities Seen in Positive Selection across Seven Complex Diseases
Positive selection is known to occur when the environment that an organism inhabits is suddenly altered, as is the case across… 
Highly Cited
2005
Highly Cited
2005
Human SNPs reveal no evidence of frequent positive selection.
We compared the single-nucleotide polymorphisms (SNPs) in humans in 182 housekeeping and 148 tissue-specific genes. SNPs were… 
Highly Cited
2002
Highly Cited
2002
Impaired Light Chain Allelic Exclusion and Lack of Positive Selection in Immature B Cells Expressing Incompetent Receptor Deficient of CD191
Positive signaling is now thought to be important for B cell maturation, although the nature of such signals has not yet been… 
Highly Cited
1997
Highly Cited
1997
TCR engagement of CD4+CD8+ thymocytes in vitro induces early aspects of positive selection, but not apoptosis.
Immature CD4/CD8 double-positive (DP) thymocytes expressing self MHC-restricted TCR are positively selected in response to TCR… 
1995
1995
Stimulation of thymocytes before and after positive selection results in the induction of different NF-kappa B/Rel protein complexes.
Positive selection triggers the differentiation of immature CD4+8+TCRlow thymocytes into TCRhigh single-positive CD4+ or CD8… 
Highly Cited
1994
Highly Cited
1994
Bcl-2 is upregulated at the CD4+ CD8+ stage during positive selection and promotes thymocyte differentiation at several control points.
Highly Cited
1993
Highly Cited
1993
CD8 is needed for positive selection but differentially required for negative selection of T cells during thymic ontogeny
During thymic development, immature thymocytes expressing major histocompatibility complex (MHC) class I‐restricted T cell… 
Highly Cited
1992
Highly Cited
1992
Isolation and characterization of human hematopoietic progenitor cells: an effective method for positive selection of CD34+ cells.
Immunomagnetic beads are well suited for positive selection of CD34+ cells. However, both unspecific binding of beads to cells as… 
Highly Cited
1990
Highly Cited
1990
Positive selection of transgenic receptor-bearing thymocytes by Kb antigen is altered by Kb mutations that involve peptide binding.
A specific interaction between the class I major histocompatibility complex molecule Kb and thymocytes expressing the antigen… 
Highly Cited
1986
Highly Cited
1986
Characterization of Human Mononuclear Cells after Positive Selection with Immunomagnetic Particles
We have investigated the possibility to employing magnetic monodisperse polymer particles for positive selection of human… 
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