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Polysorbate 20

Known as: Polyethylene glycol 2000 Sorbitan Laurate, Polysorbate 20 [Chemical/Ingredient] 
 
National Institutes of Health

Topic mentions per year

Topic mentions per year

1999-2017
02419992017

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Broader (1)

Polysorbates

Related mentions per year

Related mentions per year

1946-2018
19401960198020002020
Polysorbate 20
Tween 20
Polysorbates
Povidone-Iodine 100 MG/ML Topical Solution
Ethanol 0.62 ML/ML Topical Gel
Ethanol 0.62 ML/ML Topical Solution

Papers overview

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2016
2016
Degradation Mechanisms of Polysorbate 20 Differentiated by 18O-labeling and Mass Spectrometry
To investigate the mechanisms of polysorbate (PS) degradation with the added objective of differentiating the hydrolysis and… (More)
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2016
2016
Reduced Subvisible Particle Formation in Lyophilized Intravenous Immunoglobulin Formulations Containing Polysorbate 20.
The first goal of this study was to determine the effects of the surface fraction of protein in lyophilized formulations of… (More)
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2015
2015
Understanding Particle Formation: Solubility of Free Fatty Acids as Polysorbate 20 Degradation Byproducts in Therapeutic Monoclonal Antibody Formulations.
The purpose of this work was to determine the aqueous solubilities at 2-8 °C of the major free fatty acids (FFAs) formed by… (More)
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2015
2015
Free fatty acid particles in protein formulations, part 2: contribution of polysorbate raw material.
Polysorbate 20 (PS20) is a nonionic surfactant frequently used to stabilize protein biopharmaceuticals. During the development of… (More)
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2015
2015
Polysorbate 20 Degradation in Biopharmaceutical Formulations: Quantification of Free Fatty Acids, Characterization of Particulates, and Insights into the Degradation Mechanism.
Polysorbate 20 (PS20), a commonly used surfactant in biopharmaceuticals, showed degradation upon long-term (∼18-36 months… (More)
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2014
2014
Modifying the release properties of liposomes toward personalized medicine.
Surfactant-liposome interactions have historically been investigated as a simplified model of solubilization and breakdown of… (More)
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2013
2013
The effects of membrane filters used in biopharmaceutical processes on the concentration and composition of polysorbate 20.
Polysorbate 20 (PS-20) is often included in the formulation for therapeutic proteins to reduce protein aggregation and surface… (More)
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2010
2010
Simultaneous determination of polysorbate 20 and unbound polyethylene-glycol in protein solutions using new core-shell reversed phase column and condensation nucleation light scattering detection.
A novel fast and sensitive method has been developed for the specific simultaneous determination of polysorbate 20 (Tween 20) and… (More)
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2008
2008
Characterization and aerodynamic evaluation of spray dried recombinant human growth hormone using protein stabilizing agents.
The effect of the protein stabilizers on the stability and aerosol performance of spray dried recombinant human growth hormone… (More)
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2002
2002
A new mechanism for decreasing aggregation of recombinant human interferon-gamma by a surfactant: slowed dissolution of lyophilized formulations in a solution containing 0.03% polysorbate 20.
To study the mechanisms by which Tween 20 (polysorbate 20) used in a reconstitution solution affects the aggregation of… (More)
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