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Polysorbate 20

Known as: Polyethylene glycol 2000 Sorbitan Laurate, Polysorbate 20 [Chemical/Ingredient] 
 
National Institutes of Health

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Polysorbates

Papers overview

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2017
2017
Knockout of a difficult-to-remove CHO host cell protein, lipoprotein lipase, for improved polysorbate stability in monoclonal antibody formulations.
While the majority of host cell protein (HCP) impurities are effectively removed in typical downstream purification processes, a… Expand
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2016
2016
Residual Host Cell Protein Promotes Polysorbate 20 Degradation in a Sulfatase Drug Product Leading to Free Fatty Acid Particles.
This study investigated the root cause behind an observed free fatty acid particle formation and resulting Polysorbate 20 (PS20… Expand
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2016
2016
Polysorbates prevent biofilm formation and pathogenesis of Escherichia coli O104:H4
Abstract Escherichia coli biotype O104:H4 recently caused the deadliest E. coli outbreak ever reported. Based on prior results… Expand
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2015
2015
Polysorbate 20 Degradation in Biopharmaceutical Formulations: Quantification of Free Fatty Acids, Characterization of Particulates, and Insights into the Degradation Mechanism.
Polysorbate 20 (PS20), a commonly used surfactant in biopharmaceuticals, showed degradation upon long-term (∼18-36 months… Expand
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2015
2015
Improved neuroprotective effects of resveratrol-loaded polysorbate 80-coated poly(lactide) nanoparticles in MPTP-induced Parkinsonism.
AIM This study investigated the neuroprotective effects of resveratrol (RVT)-loaded polysorbate 80 (PS80)-coated poly(lactide… Expand
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2015
2015
Understanding Particle Formation: Solubility of Free Fatty Acids as Polysorbate 20 Degradation Byproducts in Therapeutic Monoclonal Antibody Formulations.
The purpose of this work was to determine the aqueous solubilities at 2-8 °C of the major free fatty acids (FFAs) formed by… Expand
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2011
2011
Site-Specific Tryptophan Oxidation Induced by Autocatalytic Reaction of Polysorbate 20 in Protein Formulation
ABSTRACTPurposeTryptophan (Trp) oxidation leading to atypical degradation of a protein (Fab) formulated with polysorbate 20 (PS20… Expand
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2010
2010
Aggregation of a monoclonal antibody induced by adsorption to stainless steel.
Stainless steel is a ubiquitous surface in therapeutic protein production equipment and is also present as the needle in pre… Expand
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2000
2000
Analysis of some commercial polysorbate formulations using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry.
Analyses of polysorbate formulations (Tween 20, Tween 40, Tween 60, and Tween 80) by matrix-assisted laser desorption/ionization… Expand
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1998
1998
Human keratinocyte cultures in an in vitro approach for the assessment of surfactant-induced irritation.
A specific, mechanistic, in vitro approach for the assessment of human skin irritation potential is outlined for the evaluation… Expand
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