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Polysorbate 20

Known as: Polyethylene glycol 2000 Sorbitan Laurate, Polysorbate 20 [Chemical/Ingredient] 
National Institutes of Health

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Polysorbates

Papers overview

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2019
2019
Factors Influencing Polysorbate's Sensitivity Against Enzymatic Hydrolysis and Oxidative Degradation.
The aim was to compare the sensitivity of different grades of polysorbate 20 (PS20) and polysorbate 80 (PS80) against enzymatic… Expand
2018
2018
Polysorbate 20 alters the oral bioavailability of etoposide in wild type and mdr1a deficient Sprague‐Dawley rats
&NA; The aim of the present work was to investigate the ability of nonionic surfactants to increase the oral absorption of the P… Expand
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Highly Cited
2017
Highly Cited
2017
Knockout of a difficult‐to‐remove CHO host cell protein, lipoprotein lipase, for improved polysorbate stability in monoclonal antibody formulations
While the majority of host cell protein (HCP) impurities are effectively removed in typical downstream purification processes, a… Expand
Highly Cited
2016
Highly Cited
2016
Residual Host Cell Protein Promotes Polysorbate 20 Degradation in a Sulfatase Drug Product Leading to Free Fatty Acid Particles.
This study investigated the root cause behind an observed free fatty acid particle formation and resulting Polysorbate 20 (PS20… Expand
Highly Cited
2015
Highly Cited
2015
Polysorbate 20 Degradation in Biopharmaceutical Formulations: Quantification of Free Fatty Acids, Characterization of Particulates, and Insights into the Degradation Mechanism.
Polysorbate 20 (PS20), a commonly used surfactant in biopharmaceuticals, showed degradation upon long-term (∼18-36 months… Expand
2015
2015
Understanding Particle Formation: Solubility of Free Fatty Acids as Polysorbate 20 Degradation Byproducts in Therapeutic Monoclonal Antibody Formulations.
The purpose of this work was to determine the aqueous solubilities at 2-8 °C of the major free fatty acids (FFAs) formed by… Expand
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Highly Cited
2015
Highly Cited
2015
Improved neuroprotective effects of resveratrol-loaded polysorbate 80-coated poly(lactide) nanoparticles in MPTP-induced Parkinsonism.
AIM This study investigated the neuroprotective effects of resveratrol (RVT)-loaded polysorbate 80 (PS80)-coated poly(lactide… Expand
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2015
2015
Free fatty acid particles in protein formulations, part 2: contribution of polysorbate raw material.
Polysorbate 20 (PS20) is a nonionic surfactant frequently used to stabilize protein biopharmaceuticals. During the development of… Expand
2011
2011
Site-Specific Tryptophan Oxidation Induced by Autocatalytic Reaction of Polysorbate 20 in Protein Formulation
ABSTRACTPurposeTryptophan (Trp) oxidation leading to atypical degradation of a protein (Fab) formulated with polysorbate 20 (PS20… Expand
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Highly Cited
2000
Highly Cited
2000
Analysis of some commercial polysorbate formulations using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry.
Analyses of polysorbate formulations (Tween 20, Tween 40, Tween 60, and Tween 80) by matrix-assisted laser desorption/ionization… Expand
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