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Polysorbate 20
Known as:
Polyethylene glycol 2000 Sorbitan Laurate
, Polysorbate 20 [Chemical/Ingredient]
National Institutes of Health
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Broader (1)
Polysorbates
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
2019
2019
Factors Influencing Polysorbate's Sensitivity Against Enzymatic Hydrolysis and Oxidative Degradation.
W. Kranz
,
K. Wuchner
,
E. Corradini
,
M. Berger
,
A. Hawe
Journal of Pharmacy and Science
2019
Corpus ID: 58654277
Highly Cited
2017
Highly Cited
2017
Knockout of a difficult‐to‐remove CHO host cell protein, lipoprotein lipase, for improved polysorbate stability in monoclonal antibody formulations
Josephine Chiu
,
Kristin N. Valente
,
N. E. Levy
,
Lie Min
,
A. Lenhoff
,
Kelvin H. Lee
Biotechnology and Bioengineering
2017
Corpus ID: 13925829
While the majority of host cell protein (HCP) impurities are effectively removed in typical downstream purification processes, a…
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Highly Cited
2015
Highly Cited
2015
Polysorbate 20 Degradation in Biopharmaceutical Formulations: Quantification of Free Fatty Acids, Characterization of Particulates, and Insights into the Degradation Mechanism.
A. Tomlinson
,
Barthélemy Demeule
,
B. Lin
,
S. Yadav
Molecular Pharmaceutics
2015
Corpus ID: 40481185
Polysorbate 20 (PS20), a commonly used surfactant in biopharmaceuticals, showed degradation upon long-term (∼18-36 months…
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Highly Cited
2015
Highly Cited
2015
Improved neuroprotective effects of resveratrol-loaded polysorbate 80-coated poly(lactide) nanoparticles in MPTP-induced Parkinsonism.
Gabriela da Rocha Lindner
,
Danúbia Bonfanti Santos
,
+5 authors
R. Mara Mainardes
Nanomedicine
2015
Corpus ID: 207348153
AIM This study investigated the neuroprotective effects of resveratrol (RVT)-loaded polysorbate 80 (PS80)-coated poly(lactide…
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Highly Cited
2015
Highly Cited
2015
Understanding Particle Formation: Solubility of Free Fatty Acids as Polysorbate 20 Degradation Byproducts in Therapeutic Monoclonal Antibody Formulations.
Nidhi Doshi
,
Barthélemy Demeule
,
S. Yadav
Molecular Pharmaceutics
2015
Corpus ID: 206685089
The purpose of this work was to determine the aqueous solubilities at 2-8 °C of the major free fatty acids (FFAs) formed by…
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Highly Cited
2015
Highly Cited
2015
Free fatty acid particles in protein formulations, part 2: contribution of polysorbate raw material.
C. Siska
,
Christopher J Pierini
,
Hollis Lau
,
R. F. Latypov
,
R. Fesinmeyer
,
J. Litowski
Journal of Pharmacy and Science
2015
Corpus ID: 27620939
Polysorbate 20 (PS20) is a nonionic surfactant frequently used to stabilize protein biopharmaceuticals. During the development of…
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Highly Cited
2012
Highly Cited
2012
Colloidal astaxanthin: preparation, characterisation and bioavailability evaluation.
N. Anarjan
,
C. Tan
,
I. Nehdi
,
T. Ling
Food Chemistry
2012
Corpus ID: 24044490
Highly Cited
2011
Highly Cited
2011
Site-Specific Tryptophan Oxidation Induced by Autocatalytic Reaction of Polysorbate 20 in Protein Formulation
X. Lam
,
W. G. Lai
,
Edwin Chan
,
V. Ling
,
Chung C. Hsu
Pharmaceutical Research
2011
Corpus ID: 7830804
ABSTRACTPurposeTryptophan (Trp) oxidation leading to atypical degradation of a protein (Fab) formulated with polysorbate 20 (PS20…
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Highly Cited
2000
Highly Cited
2000
Analysis of some commercial polysorbate formulations using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry.
F. Ayorinde
,
S. Gelain
,
J. H. Johnson
,
L. Wan
Rapid Communications in Mass Spectrometry
2000
Corpus ID: 24377600
Analyses of polysorbate formulations (Tween 20, Tween 40, Tween 60, and Tween 80) by matrix-assisted laser desorption/ionization…
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1998
1998
Human keratinocyte cultures in an in vitro approach for the assessment of surfactant-induced irritation.
R. Ward
,
A. W. Hubbard
,
H. Sulley
,
M. Garle
,
R. Clothier
Toxicology in Vitro
1998
Corpus ID: 22475200
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