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Polyketides

Known as: Polyketides [Chemical/Ingredient] 
Natural compounds containing alternating carbonyl and methylene groups (beta-polyketones), bioenergenetically derived from repeated condensation of… 
National Institutes of Health

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In Bloodagonistsantagonists & inhibitorschemical synthesis

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JBIR-85KetidesPM050489PM060184

Papers overview

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2018
2018
Structurally Diverse Polyketides From the Mangrove-Derived Fungus Diaporthe sp. SCSIO 41011 With Their Anti-influenza A Virus Activities
Influenza A virus (IAV) is a severe worldwide threat to public health and economic development due to its high morbidity and… 
Highly Cited
2008
Highly Cited
2008
Stereochemical determination and complex biosynthetic assembly of etnangien, a highly potent RNA polymerase inhibitor from the myxobacterium Sorangium cellulosum.
A potent novel analogue of the natural macrolide antibiotic etnangien, a structurally unique RNA polymerase inhibitor from… 
2007
2007
PCR screening reveals unexpected antibiotic biosynthetic potential in Amycolatopsis sp. strain UM16
Aims:  To assess the antibiotic biosynthetic potential of Amycolatopsis sp. strain UM16 and eight other Amycolatopsis species. 
Highly Cited
2007
Highly Cited
2007
Stereoelectronic effects dictate mechanistic dichotomy between Cu(II)-catalyzed and enzyme-catalyzed reactions of malonic acid half thioesters.
Previously we developed a Cu(II)-catalyzed, enantioselective aldol reaction between malonic acid half thioesters (MAHTs) and… 
2006
2006
Isokibdelones: novel heterocyclic polyketides from a Kibdelosporangium sp.
[Structure: see text] The isokibdelones are an unprecedented family of polyketides produced by an Australian isolate of a rare… 
Highly Cited
2002
Highly Cited
2002
Rationally designed glycosylated premithramycins: hybrid aromatic polyketides using genes from three different biosynthetic pathways.
Heterologous expression of the urdGT2 gene from the urdamycin producer Streptomyces fradiae Tü2717, which encodes a C… 
2002
2002
Bitungolides A-F, new polyketides from the Indonesian sponge Theonella cf. swinhoei.
Six new polyketides, bitungolides A-F (1-6), have been isolated from the Indonesian sponge Theonella cf. swinhoei and their… 
Review
2001
Review
2001
Engineering of complex polyketide biosynthesis — insights from sequencing of the monensin biosynthetic gene cluster
The biosynthesis of complex reduced polyketides is catalysed in actinomycetes by large multifunctional enzymes, the modular Type… 
2001
2001
Molecular basis of Celmer's rules: role of the ketosynthase domain in epimerisation and demonstration that ketoreductase domains can have altered product specificity with unnatural substrates.
Highly Cited
1999
Highly Cited
1999
The Streptomyces peucetius dpsC Gene Determines the Choice of Starter Unit in Biosynthesis of the Daunorubicin Polyketide
ABSTRACT The starter unit used in the biosynthesis of daunorubicin is propionyl coenzyme A (CoA) rather than acetyl-CoA, which is… 
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