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Polyketides

Known as: Polyketides [Chemical/Ingredient] 
Natural compounds containing alternating carbonyl and methylene groups (beta-polyketones), bioenergenetically derived from repeated condensation of… 
National Institutes of Health

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In Bloodagonistsantagonists & inhibitorschemical synthesis

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JBIR-85KetidesPM050489PM060184

Papers overview

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2012
2012
Minimally invasive mutagenesis gives rise to a biosynthetic polyketide library.
Not in the public domain: Site-directed mutagenesis of megasynthases was the key to the generation of a library of polyketides in… 
2010
2010
Handbook of Pharmaceutical Natural Products
PREFACE A Abacopternis A-D --- Azoxybacilin B Ballotenic acid and ballodiolic acid --- 7-n-Butyl-6,8-dihydroxy-3(R)-pent-11… 
2007
2007
PCR screening reveals unexpected antibiotic biosynthetic potential in Amycolatopsis sp. strain UM16
Aims:  To assess the antibiotic biosynthetic potential of Amycolatopsis sp. strain UM16 and eight other Amycolatopsis species. 
Highly Cited
2007
Highly Cited
2007
Stereoelectronic effects dictate mechanistic dichotomy between Cu(II)-catalyzed and enzyme-catalyzed reactions of malonic acid half thioesters.
Previously we developed a Cu(II)-catalyzed, enantioselective aldol reaction between malonic acid half thioesters (MAHTs) and… 
2006
2006
Isokibdelones: novel heterocyclic polyketides from a Kibdelosporangium sp.
[Structure: see text] The isokibdelones are an unprecedented family of polyketides produced by an Australian isolate of a rare… 
Review
2005
Review
2005
Recent applications of olefin ring-closing metathesis (RCM) in the synthesis of biologically important alkaloids, terpenoids, polyketides and other secondary metabolites.
With the commercial availability of well-defined ruthenium metathesis catalysts which combine high stability and broad functional… 
Highly Cited
2002
Highly Cited
2002
Rationally designed glycosylated premithramycins: hybrid aromatic polyketides using genes from three different biosynthetic pathways.
Heterologous expression of the urdGT2 gene from the urdamycin producer Streptomyces fradiae Tü2717, which encodes a C… 
2002
2002
Bitungolides A-F, new polyketides from the Indonesian sponge Theonella cf. swinhoei.
Six new polyketides, bitungolides A-F (1-6), have been isolated from the Indonesian sponge Theonella cf. swinhoei and their… 
Review
2001
Review
2001
Engineering of complex polyketide biosynthesis — insights from sequencing of the monensin biosynthetic gene cluster
The biosynthesis of complex reduced polyketides is catalysed in actinomycetes by large multifunctional enzymes, the modular Type… 
2001
2001
Molecular basis of Celmer's rules: role of the ketosynthase domain in epimerisation and demonstration that ketoreductase domains can have altered product specificity with unnatural substrates.
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