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PM060184

Known as: DNA Minor Groove Binding Agent PM060184 
A marine-derived, synthetically produced compound with potential antineoplastic activity. DNA minor groove-binding agent PM060184 covalently binds to… 
National Institutes of Health

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2 relations

Broader (2)

PolyketidesPyrones

Papers overview

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2018
2018
AACR 2018 : l’océan source de nouvelles molécules anticancer
Les composés d’origine marine constituent une source importante de substances naturelles. Cette source extrêmement diversifiée… 
2018
2018
Abstract 3840: Plocabulin, a tubulin inhibitor, presents antitumor activity in patient-derived xenograft (PDX) models of gastrointestinal stromal tumor (GIST)
Introduction: Advanced GIST is commonly treated with tyrosine kinase inhibitors (TKI) [e.g. imatinib (IMA)]. With time the vast… 
2018
2018
Abstract 5876: Exploratory testing of PM060184 compound in high-grade serous ovarian carcinoma cell lines
Purpose of the Study: Marine sponges have developed mechanisms to protect themselves from a hostile marine microenvironment. One… 
2016
2016
Abstract 3066: Anti-angiogenic properties of PM060184
Vascular supply of tumors is one of the main targets for cancer therapy. Different studies have shown that most of the… 
2015
2015
361 Phase I, open-label, dose-escalating clinical and pharmacokinetic study of the novel antimicrotubulin agent PM060184 administered over 10 minutes on days 1-3 and 15-17 every 28 days to patients…
2014
2014
Abstract 4654: Plasma, tissue and tumor pharmacokinetics of PM060184 in NSCL xenograft mouse model
Proceedings: AACR Annual Meeting 2014; April 5-9, 2014; San Diego, CA Background: PM060184 is new marine derived tubulin-binding… 
2014
2014
55 Low, frequent doses of PM060184 induce remarkable in vivo antitumor activity
2014
2014
Abstract 4534: In vivo antitumor activity of PM060184 in patient-derived xenografted tumors (avatar)
Proceedings: AACR Annual Meeting 2014; April 5-9, 2014; San Diego, CA Background: PM060184 is a synthetic marine-derived… 
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