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  • Influence
The kinetics of triclabendazole disposition in sheep.
To investigate whether the disposition of triclabendazole (TCBZ) and its metabolites in blood or bile influenced its flukicidal potency, TCBZ was administered intraruminally at 10 mg kg-1 to sheepExpand
Avermectin inhibition of larval development in Haemonchus contortus--effects of ivermectin resistance.
The order of potency of a limited range of AVMs as inhibitors of larval development was consistent with in vivo efficacy, and Resistance ratios for IVM-resistant isolates were dependent on AVM structure, with AVM B2 the most sensitive probe forIVM resistance in the isolates tested. Expand
Mode of action of benzimidazoles.
  • E. Lacey
  • Biology, Medicine
  • Parasitology today
  • 1 April 1990
Ernest Lacey examines this example of selectivity of drug action to the ubiquitous target of these drugs, the structural protein, tubulin, and investigates why benzimidazoles can selectively kill helminths and yet exhibit little or no mammalian toxicity. Expand
The disposition of albendazole in sheep.
Albendazole (ABZ) was administered intraruminally to sheep fitted with a permanent bile-duct cannula to determine if its metabolites might contribute to its flukicidal action and it is suggested that ABZ is sequestered in the liver. Expand
Avermectin/milbemycin resistance in trichostrongyloid nematodes.
  • J. Gill, E. Lacey
  • Biology, Medicine
  • International journal for parasitology
  • 1 June 1998
In-vitro assays employing the free-living stages of trichostrongyloid nematodes were used to investigate structure-activity relationships for the avermectins/milbemycins and provided some explanation for the differences between resistant isolates. Expand
Cottoquinazoline A and cotteslosins A and B, metabolites from an Australian marine-derived strain of Aspergillus versicolor.
An Australian marine-derived isolate of Aspergillus versicolor (MST-MF495) yielded the known fungal metabolites sterigmatocystin, violaceol I, violaceol II, diorcinol, (-)-cyclopenol, andExpand
Citromycetins and bilains A-C: new aromatic polyketides and diketopiperazines from Australian marine-derived and terrestrial Penicillium spp.
The structures for the Penicillium metabolites 1- 18 were assigned by a combination of detailed spectroscopic analysis, including correlation with relevant literature data, chemical derivatization, degradation, and biosynthetic considerations. Expand
A survey of bacterial diversity in ticks, lice and fleas from Australia
Bacteria isolated from ticks, lice and fleas were mostly Gram-positive (Firmicutes), although representatives from the Proteobacteria (α, β, γ subdivisions) and CFB group were also isolated. Expand
Induction of virulence factors in Giardia duodenalis independent of host attachment
It is demonstrated that initial sensitisation by host secretions reduces proclivity for trophozoite attachment, while inducing virulence factors, demonstrating early pathogenesis in Giardia involves two independent host-parasite interactions. Expand